Interesting Facts 

Pimafucin during pregnancy in different trimesters. Interaction with other drugs. How long should you take Pimafucin

Pimafucin means a modern pharmaceutical product developed for use in obstetrics and gynecology for the treatment of thrush at various stages of a woman's life, including during pregnancy. Pimafucin during pregnancy is best used in the form of suppositories (suppositories). This allows you to achieve maximum effect in a minimum period of time.

Consists of the active substance - natamycin, which is recognized as a substance with a low degree of toxicity. This makes it possible to successfully overcome the symptoms of thrush, even during the gestation period. This effect is achieved due to the fact that the components of the drug are not capable of absorption through the walls of the stomach and intestines. The skin and mucous membranes also do not have sufficient throughput that would allow the drug to be absorbed inside. Thus, the main effect of the drug is local. Accordingly, the fetus is not affected.

Can pimafucin be used during pregnancy?

There is every reason to say with absolute certainty: yes, pimafucin can be used during pregnancy. This pharmaceutical agent is one of the few agents, the use of which does not have any negative consequences for the body. It can be used without any fear, both during pregnancy and lactation. The action is of a purely local nature, does not possess systemic properties. Accordingly, it cannot affect the fetus. This is confirmed by numerous studies, both domestic and foreign. In addition, the long-term practice of its use confirms its safety.

ATC

A07AA03 Natamycin

Active ingredients

Natamycin

Pharmacological group

Antifungal agents

pharmachologic effect

Fungicidal preparations

Indications for the use of pimafucin during pregnancy

Indications for the use of the drug are cases of bacterial and fungal infections of the female reproductive organs, vagina, skin and mucous membranes. Effective against fungi of the genus Candida, accordingly prescribed for candidiasis of any localization. Treatment of thrush requires the use of pimafucin. It also eliminates various inflammatory diseases. Recommended for generalized lesions of internal organs, in which the infection spreads uncontrollably. When the infection spreads, the intestines and internal genital organs are affected. In this case, you cannot do without pills. In the event of gynecological diseases, the partner also needs treatment and prevention. It is used for lesions of the oral cavity, which can be observed with an overly weakened immunity.

From thrush during pregnancy

The onset of pregnancy brings many women a serious problem - thrush. Pimafucin will help to cope with it. The cause of thrush can be correlated with a decrease in immunity, restructuring of microflora in connection with new conditions for the body. Most experts prescribe pimafucin because it has proven itself to be non-toxic and safe. The embryo does not fall under the influence of the drug.

There is no period of pregnancy when pimafucin is contraindicated. If symptoms of illness appear, use immediately. It is important to choose the correct dosage and concentration, which can only be done by a doctor. To do this, you need to look at the analyzes. The drug can be used in various forms. If the disease is systemic, it is better to resort to pills. Suppositories will be useful for local inflammation.

With ICI during pregnancy

Isthmic-cervical insufficiency is not a contraindication to the use of pimafucin. It has a therapeutic and prophylactic effect, prevents the risk of the spread of infection, which is very important for icn.

With colpitis during pregnancy

Primafucin is active against fungi. It is used in the treatment of colpitis, if it is caused by the action of fungi, dysbiosis. It is used in the form of candles. Acts quickly, affects the entire area of ​​inflammation, protects against penetration and further spread of infection, normalizes microflora.

Release form

The drug Pimafucin is available in the form of suppositories for intravaginal and rectal administration, tablets for oral administration, ointments and cream for local application to the affected areas.

  • Pills

If the disease is prolonged, or it is difficult to treat, you need to move on to taking pills. In a chronic course, pills will also have a greater effect. For pregnant women, suppositories are the best option, but pills are also allowed.

Also, tablets are used to prevent the uncontrolled spread of infection, with a severe form of the disease, with systemic damage to internal organs.

  • Candles

Suppositories are the most convenient and affordable form for rational treatment during pregnancy. They are effective for local inflammation, as they quickly dissolve and begin to act in a short time. Allows you to bypass the gastrointestinal tract, reducing the load on it.

Sometimes it is advisable to apply a cream. It has an additional effect, enhances the effect of other forms. Recommended for use in case of protracted illness, severe form. Can be used for dermatitis, dermatomycosis, other diseases of the skin and nail plates. Provides prevention and treatment

The ointment is used in cases of damage to the reproductive organs, localization of the infectious process on the skin and nails.

Pharmacodynamics

Has antifungal (antimycotic) effect. Acts directly on microorganisms statically or lytically, depending on the dosage. With a static action, the drug helps to stop the growth and reproduction of microorganisms, due to which their population decreases and the inflammatory process subsides. With a lytic action, the drug also acts on microorganisms, causing them to disrupt genetic and metabolic processes, resulting in the death of the microorganism. It also helps to reduce inflammation.

The causative agent of thrush in most cases is microorganisms of the genus Candida, which are microscopic yeast-like fungi that are representatives of opportunistic microflora. That is, they are normally found in every healthy organism and form a natural defense. If immunity falls, as well as due to some other factors, an increase in the number of these fungi occurs. If their number significantly exceeds the permissible indicators of the norm, the disease develops.

Therefore, the action of the drug is directed against them. The required dosage is selected, which will have a lytic or static effect. The dosage should be selected only by a doctor, since a decrease in the number of these fungi in the body below the normal values ​​also entails negative consequences. Natamycin irreversibly binds to the cell membranes of fungi, the function and structure of which is disturbed, the microorganism dies. Resistance rarely develops.

Pharmacokinetics

Natamycin, which acts as an active substance, has the ability to irreversibly bind to the cell membranes of the causative agent of the disease. This leads to the fact that the microorganism dies. It works not only on candida, but also on other microorganisms that are sensitive to this ingredient. No addiction is observed.

Pimafucin has only a local effect. It does not have a toxic effect, does not lead to poisoning, even in case of an overdose.

Use of pimafucin in pregnancy during pregnancy

Pimafucin in pharmacological reference books is characterized as an antifungal drug that acts against a wide range of microorganisms. It has long been used in the treatment of thrush and andidoses. Its peculiarity is that it can be used during pregnancy, due to its high safety and lack of effect on the embryo. Many expectant mothers note that the drug has a positive effect on them, and consider it the only possible remedy to save from the manifestations of thrush.

Doctors are inclined to use this drug due to the lack of teratogenic effects and due to the resolution during pregnancy and lactation. In addition, there is no evidence of a negative effect on the embryo. Most people prefer to use candles, so they can quickly achieve the desired effect. Only if they are ineffective and the disease progresses, it is advisable to resort to the use of tablets or a combination of drugs.

If you analyze the reviews of patients who took the drug, you can note both positive and negative reviews. The positive aspects of pimafucin include: efficiency, rapid achievement of a positive effect, safety. For some women, 1-2 candles are enough, while others require several packs for a course of treatment. Many women associate the appearance of thrush with the onset of pregnancy, previously such cases have not been observed. It is used at different stages of pregnancy, but more often than not, the drug is susceptible to occur in the first months. Severely ill women used suppositories in combination with cream. When the infectious process spread to the internal organs, which was extremely rare, a tablet form was used. In especially severe cases, or with a prolonged illness, complex therapy was prescribed, which included suppositories and tablets.

Usually one or two courses are enough to completely recover. Relapses are rare. Some women note skin pathologies, which can be easily dealt with with a cream. The effect of the cream is noticeable after an hour. Suppositories usually completely eliminate the symptoms of the disease in 6-7 days.

There are also negative reviews. For some women, the drug does not work in any way. Perhaps this is due to individual resistance, the characteristics of microflora. Despite the safety of the drug and the fact that it can be safely taken throughout pregnancy, some doctors prefer to refrain from prescribing it for the first three months. Some women complain of relapses, suffer throughout pregnancy, despite taking the drug. They also say that there are candles that are also approved for use during pregnancy and are more effective. Sometimes there is even an increase in the manifestations of thrush.

Thus, reviews of the drug are very controversial. There are both positive and negative ones. This indicates an individual sensitivity to the drug, which is quite natural. In each specific situation, the result will be different. In any case, before use, you need to consult a doctor, do not engage in self-medication in any case. And in any case, you need to try: after all, the drug can be effective, and will help to heal forever.

Pimafucin in the first weeks and early pregnancy

If a woman is in the first week of pregnancy, pimafucin can be used. It is at this stage that it is most often prescribed, since in the first weeks most of the milkmaid sulchas are registered, which is explained by a decrease in immunity. The drug does not interfere with the development of the embryo, does not interfere with the implantation process.

If signs of thrush are found, you can safely start taking pimafucin. It is non-toxic, does not have a negative effect on the fetus. The course of treatment is short-lived. Recovery occurs quickly, relapses are rare.

Pimafucin during pregnancy in the 1st, 2nd, 3rd trimester

Pimafucin is quite safe when used in the first trimester of pregnancy.

From 3 to 6 months, the drug can be used, since it has only a local effect, due to which it acts effectively and quickly.

If necessary, the drug can be used from 6 to 9 months. It is a safe, non-toxic drug. But usually the need for it arises at an earlier date. Thrush at 6-9 months is a rare phenomenon, since immunity increases.

Contraindications

Pimafucin has no toxic effect, therefore it has no contraindications, except in cases where there is an individual intolerance to its components.

Side effects of pimafucin during pregnancy

Side effects include nausea and diarrhea. These effects pass quickly enough and do not require any additional treatment. When applied topically in the form of suppositories, there may be a feeling of discomfort, burning sensation in the genital area. These symptoms also pass quickly enough without additional intervention.

Discharge and burning after pimafucin during pregnancy

The discharge may increase due to the fact that the candle in the vagina melts and flows out. Also, as a result of irritation of the receptors of the mucous membrane, additional stimulation of the production of mucus occurs.

With intravaginal administration of a suppository, or when applying a cream to the external genital organs, irritation of the mucous membrane may occur, as a result of which there is a burning sensation and itching. It goes away on its own after a while. It is not worth stopping treatment, no measures need to be taken.

Method of administration and dosage

When carrying out systemic therapy, take pills. Dosage - 1 tablet 4 times a day. The duration of treatment is 7 to 10 days. The dose can be exceeded, since overdose cases are unknown.

When prescribing suppositories, usually 1 suppository is prescribed daily, or every other day. Depending on the form and severity of the disease, one suppository can be used once a week, or two weeks. One may need 3-4 candles per course, others - several packs.

How often can pimafucin suppositories be used during pregnancy?

The drug is used until the symptoms of the disease are eliminated. The amount of the drug is individual. Can be applied every other day, or several times a week. In any case, only a doctor can determine the required dosage, based on the test results.

How to insert pimafucin suppositories during pregnancy?

Pimafucin suppositories are inserted deep into the vagina at night. You can use the applicator for the introduction of suppositories for injection. For this, the candle is placed in a special applicator, inserted into the vagina, released from the applicator, and removed. The applicator can be purchased at the pharmacy. It ensures sterility of administration and deeper penetration of the agent.

Overdose

Overdose cases are currently unknown. Long-term use of the product does not entail any consequences, does not affect either the mucous membranes or the condition of the skin. Does not affect the fetus. The toxic effect does not occur even when taking a large amount of the drug inside, since it is not absorbed through the intestinal mucous membranes.

Interaction with other drugs

The drug is combined with other drugs, cross-reactions and mutual neutralization does not occur.

Pimafucin and pregnancy during pregnancy

The two drugs are combined with each other, the main thing is to distribute the order and method of their introduction into the body. There are several options: you can apply intravaginally, and pimafucin - rectally. However, it should be borne in mind that with this method of administration, the effectiveness of pimafucin may decrease and the expected results may not be achieved. Or the duration of the treatment will be much longer.

The second option is to take urozhestan in tablets, inject pimafucin intravaginally. This option is also not devoid of its drawbacks - morning sickness can have a toxic effect on the liver. However, the effectiveness of any drug is not reduced. Utrozhestan has the same effect on the body, both with vaginal and oral administration. Its main task is to deliver progesterone to the body.

The third option is to inject both drugs intravaginally, with a break of at least 2 hours. This is the most optimal option, since the effectiveness does not decrease from this, side effects and drug interactions do not occur. It is not worth injecting two drugs at the same time, you need to take breaks between them.

Storage conditions

The drug should be stored at a temperature not exceeding 25 ° C, in its original packaging. Direct sun rays should not fall.

Shelf life

The drug can be stored for 2 years.

What if pimafucin doesn't help during pregnancy?

The action of the drug is individual. Despite the fact that most women during pregnancy are saved from thrush only with this remedy, for some it may be completely useless. It all depends on the individual characteristics of the organism, in particular, on the sensitivity of the microflora to the active substance. Resistance can develop if a woman has been taking the drug for a long time, or if the previously prescribed courses have not been completed.

Treatment with antibacterial and antifungal drugs has its own characteristics. It is necessary to undergo a full course of treatment, even if the symptoms of the disease no longer bother and the body is completely healthy. This is due to the fact that microorganisms against which the drug is directed can develop resistance over time. The full course is designed to completely kill the pathogen. If you quit using the drug halfway through the course, as soon as the symptoms have disappeared, microorganisms may not die completely. They survive and, by natural selection, develop in themselves further resistance not only to this drug, but to the entire group of these drugs. Since the microorganisms have not died, after a while they can cause the disease again, but the drug will no longer act on them.

Also, if the drug does not work, you need to check the expiration date. Perhaps, the period of its suitability for use has simply expired, and the healing properties have been lost.

Pimafucin analogs during pregnancy

The closest analogue is natamycin. He is also the active ingredient that is part of pimafucin. In its pure form, it is less effective, since pimafucin contains excipients in its composition. Also, in its pure form, natamycin can harm the stomach and intestines. Dysbiosis may occur.

Clotrimazole

It is better to use pimafucin during pregnancy, since it is safer and approved for use while carrying and feeding a baby. Clotrimazole is not recommended to be taken in the 1st trimester of pregnancy and during breastfeeding. An overdose causes severe intoxication, while pimafucin has no side effects in case of an overdose. In case of an overdose of clotrimazole, in contrast to pimafucin, additional therapy is required.

Livarol

It is best to use pimafucin as it is more safe. Pimafucin has fewer side effects (in rare cases - diarrhea, nausea, only at the initial stages of administration). When taking livarol, irritation, severe dizziness and nausea may occur. In addition, the drug can cause severe allergic reactions, therefore, it is contraindicated for people who suffer from allergies. Increases the amount of histamine in the body (which can already be increased during pregnancy). In this case, severe edema, headaches, dizziness, drowsiness can be observed. The drug is contraindicated in the first trimester.

Terzhinan

Better to use pimafucin. First, it is easier to type. Before the introduction of terginan, the tablet is pre-soaked in water. The tablet form is not convenient for insertion into the vagina. Pimafusin suppositories have a more convenient, natural form, do not cause discomfort when administered. Secondly, the duration of the course with terzhinan is much longer - 10-20 days, while pimafucin is treated for 5-7 days. Terzhinan can cause aallergic reactions, it is contraindicated in the 1st trimester, since it penetrates transplacentally and affects the fetus. Use when breastfeeding is possible only in extreme cases.

In addition, terginan is more often used in the presence of a secondary inflammatory process, with a combination of thrush with other pathologies, or with a severe form of fungal infection.

Hexicon

During pregnancy and breastfeeding, both Hexicon and Pimafucin can be used. But it should be borne in mind that pimafusin causes allergic reactions and should be used with caution by people with allergic diseases. Also, taking Hexicon may be accompanied by excessive dryness, stickiness of the skin of the face and hands, overdrying of the mucous membranes. There may be a deposit of an accumulation stone, plaque. Sometimes the reception of Hexicon is accompanied by a taste disturbance. Does not combine with chlorhexidine. Brown spots may form if hexicone comes into contact with a surface previously treated with chlorhexidine. Also, the drug is incompatible with iodine. It should be borne in mind that soap neutralizes the drug, therefore, before applying the drug, it is necessary to completely remove even the slightest soap residues on the skin and mucous membranes.

Betadine

For thrush, it is better to use pimafucin, since its main action is directed against the fungus. Betadine has predominantly antibacterial properties. Antifungal activity is in second place. Batidine has a more powerful antiseptic effect. This may have its drawbacks - dry mucous membranes, burns. Pimafucin is safer during pregnancy, it acts mildly. Betadine is more often used to treat skin, postoperative surfaces, trophic ulcers and pressure sores. The instructions do not say that the drug is recommended for application to mucous membranes. There is no question of its use during thrush. The drug should not be used in the first trimester, as it can affect the fetus. In addition, it contains iodine, therefore, with prolonged use, it is imperative to check the function of the thyroid gland. In newborns whose mothers used betamine, congenital thyroid dysfunctions are observed.

It's important to know!

Hyperhomocysteinemia is a multifactorial process involving genetic and non-genetic mechanisms. The causes of hyperhomocysteinemia can be hereditary and acquired. Hereditary factors can be divided into enzyme deficiency and transport deficiency.

Due to the heavy load on a woman's immunity while carrying a child, it is more difficult for her body to defend herself against infection. Most often, expectant mothers complain about the manifestations of thrush, which is confirmed after the delivery of a genital smear. In such cases, experts recommend treatment with Pimafucin - it is the safest during pregnancy. Before use, you must carefully read the information about the features of its effects, dosage and contraindications.

Pimafucin - what is this medicine?

Pimafucin is an antifungal antibacterial agent from the macrolide family that has a bacteriostatic effect due to the binding of styrene and blocking the process of joining the membranes of the fungal cell. The active component of the drug is a broad-spectrum antimycotic - natamycin, which acts on the cell walls of pathogenic microorganisms of candidiasis pathogens, preventing their reproduction.

Experts use this medicine to treat not only thrush caused by candida albicans, but also any other lesions of a fungal infection:

  • ear inflammation (otitis externa and otitis media);
  • stomatitis;
  • mycosis of the nail plate and skin;
  • inflammation of the vulva and vaginal mucosa (vulvovaginitis, vaginitis).

It is prescribed even to pregnant women infected with fungi. It is considered absolutely safe due to the fact that it has a local therapeutic effect - it does not penetrate the circulatory system and through the placental barrier, therefore, according to medical statistics, not a single case of a negative effect of Pimafucin on the development of fetal organ systems has been recorded.

Release form, dosage and effect on the body

Pimafucin is available in different dosage forms according to the area of ​​application (inside or outside). Only a doctor can select the type and dosage of the drug or combine both forms:

  • Ointment or cream 2% (1 gram contains 20 mg of natamycin) for external use, odorless, white or light yellow in color with a uniform thick texture. The cream is packed in an aluminum tube with a volume of 30 grams, which is accompanied by a cardboard box and detailed instructions.
  • Vaginal suppositories in the form of a milky-white torpedo containing 100 mg of antibiotic in 1 suppository. Additional substances: adipic acid, sodium bicarbonate, polysobate, cetyl ethanol, solid fat, sorbitan trioleate. The drug is packed in cardboard boxes with three 3 or 6 strips.
  • Round white enteric coated tablets. 1 piece contains 100 mg of natamycin and 160 mg of auxiliary components: potato starch, lactose monohydrate, magnesium stearate, polyvinylpyrrolidone. Tablets are packaged in 20 pieces in dark glass bottles and cardboard boxes with instructions.

Instructions for use of the drug

Experts emphasize that not a single drug, even the safest one, can be selected independently. Pimafucin also has its own characteristics of use and the duration of the course, depending on the form of release:

  • The cream is applied to the affected areas of the skin or nails, placed in the ear canal up to 4 times a day during the course, which is individually selected by the attending specialist, until the symptoms disappear completely.
  • Suppositories are treated for 5 days or a week. Injected deep into the vagina, 1 piece per day. First, you need to carry out hygiene procedures, lie on your side and wait a little before dissolving.
  • The tablet form of Pimafucin is taken within a week, 1 tablet 4 times a day.

When planning

It is believed that when planning a child, Pimafucin in the form of suppositories can affect the fertility of sperm entering the vagina. Experts do not confirm this information and offer to pass all the necessary tests before conception, then undergo treatment and start conceiving a healthy baby.

1 trimester

In the first three months after the onset of pregnancy, a woman's hormonal background changes sharply and in this regard, symptoms of thrush may appear, so the gynecologist prescribes Pimafucin in the form of suppositories. Tablets in the first trimester are not recommended due to manifestations of toxicosis.

2 trimester

Treatment of a fungal infection in the period from 4 to 6 months of pregnancy (2 trimester) becomes much easier, because other, more potent drugs can be selected if Pimafucin does not cope with the developing disease. In addition, the mucous plug of the uterus protects the baby and the infection cannot penetrate to him. The specialist prescribes the drug in tablet form so that by the time of birth the child passes through the healthy birth canal and does not become infected.

Often, doctors recommend simultaneous treatment of both sexual partners and prescribe Pimafucin tablets in combination with another antifungal ointment or suppositories. The duration of treatment and additional medications are determined by the doctor according to individual indications after taking tests (vaginal smear, bacterial urine culture).

3 trimester

Experts recommend taking a preventive course of treatment before childbirth (at 38 weeks) if there was a case of recurrence of thrush during the planning period or in early pregnancy. Also, in the last stages of gestation, intestinal candidiasis may appear, which requires taking Pimafucin for 3 days.

With thrush

Thrush does not pose a danger to the fetus, it only gives unpleasant sensations to the expectant mother. However, there is a possibility of infection of the baby during labor, therefore, it is imperative to treat thrush, especially since Pimafucin does not affect the intrauterine development of the child, but only eliminates fungi and the consequences of their activity.

Side effects and contraindications

With careful observance of the instructions, Pimafucin does not have a negative effect on the body, in rare cases, side reactions may occur. In the first days of taking the pills, nausea, decreased appetite, and vomiting may occur. When using suppositories and ointments, local allergic reactions may appear in the form of itching, burning and redness of the skin areas treated with the drug.

Pimafucin has no contraindications and experts can recommend it during pregnancy and during breastfeeding. Restriction of use may be due to individual intolerance (lactase or fructose deficiency) or allergic reactions to any auxiliary component of the drug.

Are there any analogues of the drug?

In the absence of a therapeutic effect from Pimafucin, the doctor can replace it with a drug of similar action, but with a different active or auxiliary substance. The pharmaceutical industry offers many analogues:

  • Natamycin is a preparation containing a similar active substance, but without auxiliary components that soften the effect of the antibiotic on the body, which is why Natamycin causes serious harm to the patient's digestive system.
  • Funzol is an antifungal agent based on fluconazole in the form of a solution for infusion, powder for suspensions, capsules and syrup. It has many contraindications, including the period of breastfeeding.
  • Ekofucin is a complete analogue of Pimafucin in the form of suppositories, which is cheaper (200 - 300 rubles). Ecofucin is most often prescribed for pregnant women to treat thrush.
  • Funginok - tablets with the active ingredient ketonazole (200 mg), are used to treat fungal infections of the skin. Forbidden for use during pregnancy.
  • Terzhinan - tablets for vaginal administration with the following active substances: ternidazole, neomycin sulfate, nistanin, prednisolone sodium metasulfobenzoate. They are used for an inflammatory process complicated by additional pathology, and also require a longer course of treatment and can cause allergies. Terzhinan is prohibited during pregnancy, because substances penetrate the placental defense and negatively affect the fetus.
  • Clotrimazole is a medicine that has a more aggressive effect on the body and causes intoxication in case of an overdose (we recommend reading :). Not recommended for the treatment of pregnant women in the 1st trimester and breastfeeding.
  • Livarol - vaginal suppositories with the active substance ketoconazole. They are prescribed in case of recurrence of thrush, if drugs of a more gentle action do not cope. Livarol can provoke allergic reactions and severe irritation of the mucous membranes and skin.
  • Geksikon is an antiseptic drug based on chlorhexidine bigluconate, available in several forms (gel, suppositories, tablets) (we recommend reading:

Candidiasis (thrush) is one of the most common fungal diseases of the genitourinary system, which causes a lot of trouble for women and, in the absence of proper treatment, can provoke the appearance of irreversible consequences for the fetus during pregnancy.

The most effective and safe drug for thrush is "Pimafucin", which is based on the active substance natamycin antibiotic, which has a wide spectrum of action. Once in the body, it acts destructively on the membranes of fungal cells and is one of the permitted drugs during pregnancy. However, "Pimafucin" during pregnancy of the 1st trimester, according to reviews of many women, is prescribed by doctors only in the form of a cream or suppositories.

Forms of release and therapeutic effect of the drug

The main feature of the drug is the fact that it does not enter the bloodstream even when taking pills. Therefore, "Pimafucin" during pregnancy in the 1st trimester is safe for the fetus and the already born baby who is breastfed. The causative agents of thrush (Candida albicans) are very sensitive to it, so the disease is effectively cured with this drug, and it also affects other types of fungi.

There are three main forms of Pimafucin:

  • Tablets in glass bottles (at a price within 500 rubles for 20 pcs.) - have a shell that dissolves in the intestine, therefore, diseases are well treated with damage to organs located in the lower part of the digestive tract.
  • Cream in tubes of thirty grams (the price is within 300 rubles) - white or slightly yellowish. It is applied to the affected areas of the mucous membrane and skin.
  • Vaginal suppositories (price for three pieces - within 300 rubles) - torpedo-shaped suppositories, white with a brownish tint. Used to treat the vaginal mucosa. Dissolution over the entire surface begins at body temperature. It is "Pimafucin" suppositories that are most often prescribed by doctors during pregnancy in the 1st trimester, since this form of medication is the most effective in treating vaginal candidiasis.

On the other hand, due to the fact that the antibiotic natamycin does not enter the bloodstream, treatment may have a longer period, depending on the neglect of the disease.

Why should you stop taking pills in the first trimester of pregnancy?

During the onset of pregnancy, a complete restructuring of the body occurs, the hormonal background of a woman changes, and immunity sharply decreases. Therefore, in the first and second trimester, the likelihood of thrush is high, and this is statistically confirmed.

Treatment with "Pimafucin" during pregnancy of the 1st trimester has a number of limitations. This period is the most difficult and important - for both the woman and the embryo. In the future baby, all organs and the musculoskeletal system are laid. In addition, in the first three months, many women suffer from toxicosis, in which nausea and vomiting are frequent. Therefore, "Pimafucin" during pregnancy 1 trimester in tablets is excluded. But at the same time, you should not neglect the disease. This is fraught with the intensive development of fungal microflora, which will complicate the course of pregnancy. When using Pimafucin suppositories during pregnancy of the 1st trimester, reviews indicate a good effect in many cases already with three days of treatment, while the course of analogues from other manufacturers is 10 days.

In the discussions on the forum about "Pimafucin" during pregnancy of the 1st trimester, there is a quick recovery and the absence of any consequences from the treatment with candles and cream. If the disease progresses, then the course can be extended to nine days. Suppositories are inserted as deep as possible into the vagina every evening before going to bed in a supine position. It is not recommended to get up right away, since when dissolved, the candle becomes liquid and may spill out without having a therapeutic effect. When treating with suppositories, it is recommended to use sanitary panty liners, since drug residues may flow out in the form of a slightly foamy mass. Some women are worried that they have to use the antibiotic that is part of the drug, but otherwise the fungal infection cannot be defeated.

Advice! During treatment with the drug, it is recommended to combine it with sauerkraut dishes and the consumption of pickled cucumbers (but not canned) that have undergone a fermentation process. The probiotics contained in these products enhance the effect and at the same time prevent the spread of infection in the urinary tract.

Cravings for salty foods during pregnancy go well with medication. In addition to suppositories, "Pimafucin" cream is also used during pregnancy in the 1st trimester, prescribed by a doctor. It is applied several times a day, but this type of treatment is auxiliary. The drug in the form of a cream can be prescribed for men if the spouses are ill at the same time or for protection as a prophylactic agent. Thus, "Pimafucin" in tablets during pregnancy of the 1st trimester is not prescribed for women.

Features of the second trimester of pregnancy with candidiasis

The considered treatment of candidiasis in the first trimester is used in case of a strong manifestation of the disease. Gynecologists still try to avoid the use of drugs in the initial three-month period immediately after conception, since at this time, in addition to laying the basic systems of vital activity, the baby's brain is simultaneously formed. Therefore, the first trimester is a period requiring especially careful self-care with the control of all body reactions. The desirable use of "Pimafucin" during pregnancy in the 2nd trimester is simply explained: the child is more protected during this period, and it is much easier to choose the right treatment.

With the seeming safety of the drug "Pimafucin", candles during pregnancy of the 2nd trimester cannot be used independently without a doctor, since you can get a completely opposite effect.

Doctor's prescriptions will depend on the clinical picture of the disease. Thrush does not affect the development of the fetus and the bearing of the fetus. The human body is designed so that foreign bacteria cannot enter the uterus. The mucous plug reliably blocks the path of infection, neutralizing microorganisms. The fetus feeds through the placenta and continues to develop. During childbirth, the mucous plug comes out and the baby is born. Candidiasis during childbirth can provoke infection of the baby at the time of passing through the birth canal. Therefore, compulsory treatment with "Pimafucin" is recommended during pregnancy in the 2nd trimester, which will help to fully recover by the time of childbirth.

In case of severe relapse or exacerbation of the disease, "Pimafucin" is prescribed in tablets during pregnancy 2 trimester. It is necessary to understand that the born child is very weak and has no immunity. It takes some time to adapt, so any fungal infections must be ruled out as early as possible. For this, doctors prescribe a comprehensive treatment. According to the reviews available on the network, the "Pimafucin" suppositories during pregnancy of the 2nd trimester have worked well and quickly normalize the flora of the mucous membrane. In any case, caution is required with treatment, and the tablets are best used in the third trimester.

Third trimester: "Pimafucin" - a reliable barrier against fungal infection

Features of the manifestation of pregnancy in the third trimester:

  • preparation of a woman's body for childbirth;
  • an increase and a sharp increase in the weight of the baby in the womb;
  • decreased immunity of the expectant mother;
  • soreness in the lower back, swelling.

In addition to the standard set of signs of malaise, there may also be individual deviations in the state of a woman's health. In the case of thrush on this background, complex therapy is used. As a rule, candidiasis in the last stages can also develop due to a decrease in immunity, changes in hormonal levels, and a violation of hygiene. It is believed that "Pimafucin" during pregnancy 3 trimesters can no longer affect the fetus so much. Practice has shown that often during this period, thrush with a high degree of probability can return if a woman suffered from this ailment before pregnancy. Studying reviews about the treatment with "Pimafucin" during pregnancy of the 3rd trimester, you can also come across negative opinions that mark the occurrence of abdominal pain while taking the pills. In this case, the doctor revises the dosage or completely excludes the pill treatment.

Sometimes in the last weeks of pregnancy, candidiasis begins to manifest itself like other diseases, while the discharge with an unpleasant odor intensifies. They can be thick or thin, itching worsens, and the skin of the genitals turns red. The delivery of smears and examination by a gynecologist quickly reveal a picture of the disease. In addition, the opinion that candidiasis is a disease of women is erroneous. This infection can also affect the skin of the male penis. In this case, he is prescribed "Pimafucin" cream during his wife's pregnancy in the 3rd trimester, and with a particularly strong manifestation of the disease and pills inside for a complex effect and a quick cure. Depending on the form of infection, the treatment of the glans penis is carried out up to four times a day, and the duration of the procedures is determined only by the doctor, but not less than a week.

"Pimafucin" in tablets during pregnancy 3 trimester is prescribed in the case of intestinal candidiasis. The regimen and dosage are calculated by the doctor depending on the severity of the disease. As testimonials testify, "Pimafucin" suppositories during pregnancy in the 3rd trimester do an excellent job literally in three doses, and childbirth takes place without any pathology.

The disease in the last weeks is fraught with the following danger:

  • the possibility of infection of the child with a fungal infection while moving along the birth canal;
  • the existence of a risk of infection of the amniotic fluid;
  • provoking premature birth if treatment is not carried out on time.

Candidiasis is not a harmless disease and requires quality treatment.

The dosage of the drug depends on the degree of the disease:

  • Tablets - one piece four times a day for a week in the treatment of infections in the intestines and skin.
  • Cream - for skin lesions, it is applied externally up to four times a day. It can be used to treat fungal diseases in the ear canal using specially twisted turunda. The cream is successfully treated for vulvitis and vulvovaginitis.
  • Suppositories - used in any period of pregnancy, one suppository per day. Are introduced lying down before bedtime.

Treatment with the drug should be carried out only as directed by a doctor, since a similar symptomatology can be caused by a completely different infection, and the effectiveness depends on the correctness of the chosen course.

Contraindications and the possibility of side effects

Like any drug, Pimafucin can have side effects. For example, suppositories cause increased itching, burning, redness of the skin, pain. This may be due to the body's intolerance to natamycin or other components.

Possible side reaction:

  • nausea and vomiting;
  • stomach ache;
  • allergies and itching;
  • diarrhea and other symptoms.

If at any time during treatment before pregnancy a woman had an allergy, it is recommended that you inform your doctor about it.

Despite the fact that "Pimafucin" is considered a harmless drug, doctors do not have a consensus on its appointment in different trimesters of pregnancy. Some gynecologists consider it ineffective, outdated. Another part avoids prescribing even suppositories in the first trimester. At the same time, "Pimafucin" during pregnancy 3 trimesters is prescribed by them without restriction, but within the limits of the permissible dosage. And the third group calmly uses the medicine throughout the entire period of pregnancy. Analysis of the therapeutic effect showed that this drug is not suitable for everyone, but in most cases, healing was still observed. And this is consistent with numerous patient reviews.

Pimafucin tablets during pregnancy are often prescribed to women to treat a common disease - thrush. We will tell you about the indications and contraindications for the use of Pimafucin during pregnancy in our article.

Pregnancy is the most beautiful and long-awaited time in the life of every woman. But very often it is overshadowed by such an unpleasant accompanying disease as thrush (or vaginal candidiasis). And in order to get rid of it, you need to approach this issue with all seriousness. After all, being in an interesting position, a woman should be very careful about the choice of medicines, choosing not only effective, but also, first of all, safe for the fetus.

How does Pimafucin work?

Features of the therapeutic effects of Pimafucin:

  • this drug is a broad-acting antifungal antibiotic, fungi of the Candida family are most sensitive to it;
  • natamycin - the main component of the drug - destroys the cell walls of pathogenic microflora, after which it dies;
  • the drug does not enter the bloodstream, does not cross the uterine-placental barrier, including when taking the tablet form, therefore it does not pose a threat during pregnancy or lactation, and is also safe for treating newborns;
  • does not cause allergic reactions;
  • used by dermatologists for fungal infections of the skin.

What forms of Pimafucin can be found in pharmacies?

For higher efficiency and a wider spectrum of action, manufacturers produce Pimafucin in different forms, their choice is set by the attending gynecologist situationally, depending on the indications and severity of the disease:

  • Pimafucin suppositories (vaginal suppositories) are the most popular option for pregnant women, since it acts directly on the vaginal mucosa, eliminating the causative agent of vaginal candidiasis;
  • Pimafucin tablets are coated with a membrane that is resistant to stomach enzymes and dissolves already in the intestine. This form is prescribed for a chronic disease, or if the fungal infection has spread to the lower abdominal organs, which are not amenable to the action of vaginal suppositories;
  • Pimafucin cream during pregnancy is used for local external action, acts on damaged skin or mucous membranes; can be used by a partner to prevent relapse.

Pimafucin is available in several forms, which allows it to be more effective against fungi.

Indications for use

A little about thrush

Thrush (candidiasis) is one of the most common diseases among women, including pregnant women. It received this name from the causative agent - Candida fungi, an increase in the number of which leads to inflammatory processes of varying severity.

Often, thrush in women occurs against the background of a weakened immune system, intestinal dysbiosis, constant stress, and other diseases of the reproductive system.

About one in three pregnant women also face this problem. An unstable hormonal background, an additional load on the body, weaken the immune system, in addition, the vaginal microflora changes. All this is the reason that the immunity of a pregnant woman becomes easily vulnerable, and as a result, a favorable environment is created for the development of diseases such as candidal vulvitis, vaginitis, vulvovaginitis.


Women, including pregnant women, quite often face thrush.

Other possible causes of candidiasis include:

  • taking antibiotics;
  • the presence of pathogenic fungi in the intestines, their reproduction;
  • infection from a partner;
  • malnutrition;
  • use of underwear made of synthetic fabrics.

Thrush is usually manifested by symptoms typical of other genital diseases. This is a light, white-yellow vaginal discharge, often cheesy, with a sour odor. In addition, the skin and mucous membranes of the external and internal genital organs are irritated, as a result of which there is itching, burning, discomfort during intercourse or urination. It is not necessary for all symptoms to appear at the same time.

If you notice at least one of the symptoms, such as curdled discharge, itching, burning, you should contact your gynecologist for examination.

For pregnant women, the presence of this unpleasant disease in the body is especially undesirable and even dangerous. Like any other inflammatory process, thrush can adversely affect the course of pregnancy. In especially severe cases and complications, vaginal candidiasis can provoke a thinning of the amnion (fetal membrane), which can lead to its rupture prematurely. There is another danger: the baby can become infected with fungi during the passage of the birth canal during birth.

In this regard, the treatment of thrush in pregnant women or those planning to become a mother should be carried out under the close supervision of a doctor and only with those medications that do not harm the health of the woman and the unborn baby.

It should be noted that most women have fungi of the Candida family, and in normal quantities, with sufficient protective mechanisms of the body, they do not manifest themselves in any way and do not require treatment. But at any time, a fungal infection can be triggered by a decrease in immunity. Then a woman should contact a specialist for examination and prescription of treatment, so as not to transfer the process to the stage of a chronic disease.


This is what Candida fungi look like.

In addition to vaginal candidiasis, there are other indications for the use of Pimafucin. Here are the main ones:

  • vaginal candidiasis (colpitis, vulvitis, vulvovaginitis)
  • lesions of the gastrointestinal tract fungus
  • systemic fungal diseases
  • fungal diseases of the skin and nails
  • ear mycosis
  • dermatomycosis, etc.

Reception of this drug is carried out as directed by the attending physician after examination and confirmation of a pathogenic fungal infection (for example, after taking a smear from the vagina).

What are the contraindications to the use of Pimafucin in pregnant women?

The main active ingredient of this drug (natamycin) does not enter the blood system and other tissues, an overdose does not lead to intoxication of the body, therefore there are no contraindications for taking this drug.

The only thing that should be paid attention to is the individual intolerance of the individual components of the drug. Therefore, carefully study the composition of the medicinal product before taking it.

How can Pimafucin affect the course of pregnancy?

To make sure that the drug is safe for pregnant and breastfeeding women, carefully read the instructions for it, which clearly states that there is no harmful effect on the fetus. The principle of the drug's action was described above.

I trimester

Usually, in the first trimester, doctors try to limit the intake of medications to a pregnant woman as much as possible, since the placenta has not yet formed, and all components in the mother's cut reach the child. But even in this trimester, the use of Pimafucin is allowed, since it is not absorbed into the bloodstream and has a local effect. Usually at this time, Pimafucin is used in the form of vaginal suppositories.

II trimester

The second trimester for pregnant women is the most prosperous, because the baby in the womb is already protected by the placenta, the expectant mother gradually gets used to the new condition, and toxicosis passes. And at this time, doctors are already allowing the use of stronger drugs for the treatment of various kinds of infections. Pimafucin in this trimester also does not pose a threat to the fetus, now it can be recommended in the form of tablets if suppository treatment is not enough.

III trimester

Do not forget that even taking into account the safety of the medicinal product, Pimafucin should be taken strictly as prescribed by the doctor and after the examination.
The gynecologist will determine the severity of the disease and the required dosage of the drug. Do not self-medicate, because at first glance, signs of thrush may turn out to be symptoms of a more serious disease, which can be determined only after passing the necessary tests.

What side effects can be from taking "Pimafucin" in pregnant women?

As a rule, this drug is easily tolerated by pregnant women. Sometimes, when taking suppositories and cream, irritation, burning, redness may occur at the site of action of the drug. The pills can increase toxicity, cause nausea and upset stomach. But usually these manifestations do not last long and go away on their own after 2-3 days.

The main contraindication when taking Pimafucin is an individual intolerance or allergy to the accompanying components of the drug. Therefore, if you experience any other reactions not described above, stop taking the drug and consult your doctor.


If you follow the instructions and listen to the instructions of the attending physician, thrush will pass quickly and without consequences.

How long should you take Pimafucin?

The dosage of the drug, the form and duration of administration is calculated by the attending physician based on the severity of the disease.

Usually, treatment with vaginal suppositories lasts from 3 to 9 days, with tablets - 7-10 days. It all depends on the performance and well-being of the woman.

One course of medication is often enough to get rid of this unpleasant disease. Sometimes the doctor may recommend taking the drug for another 2-3 days after the symptoms disappear to "consolidate" the effect.

Pregnancy is often accompanied by candidal colpitis, which brings a lot of inconvenience to a woman. And you always have to choose between effective and safe drugs, especially up to 12 weeks, when any negative impact can disrupt the normal process of embryo development.

One of the most popular and affordable drugs is pimafucin, which is approved for use in early pregnancy without any restrictions. How and when to use it correctly and what is better to choose - candles, cream or tablets?

Read in this article

Composition and properties of the drug

Pifamucin is based on the active ingredient natamycin, a drug that belongs to the polyene group and has antifungal activity. It is noteworthy that there is no sensitivity to this drug from the side, for example, Candid. This opens up wide possibilities for drug therapy.

This drug is presented in various forms - tablets, ointments and suppositories. Therefore, for each clinical option, you can choose your own, the most suitable one.

As for the tablets, each contains 100 mg of the main active ingredient.

How does it work

Natamycin interacts with certain structures of the pathogen envelope. So he violates the foundations of their life, as a result, this leads to death.

A feature of the capsules is that when taken orally, they act only in the intestine, without being absorbed into the systemic circulation. The same is true when using skin ointments - only local action. That is why pimafucin and its analogues can be safely used during pregnancy, even in the early stages.

Indications for use

Pimafucin is used to treat all conditions when pathogenic microorganisms, in particular fungi, are sensitive to it. Preference is given in the following situations:

  • With, vulvovaginitis, vulvitis (involving not only the vagina, but also the external genital organs in the process).
  • If necessary, sanitize the intestines from fungi. Often this need arises in case of serious immunodeficiency conditions (including HIV), while taking cytostatics and antibacterial drugs, hormonal agents.
  • In case of systemic fungal infection. In this situation, pimafucin can be used both externally and internally.

Before using the drug, you should make sure that the pathogenic flora is sensitive to it.

Is it possible during pregnancy

Pimafucin can be safely used during pregnancy throughout the entire gestation period. The drug does not have a detrimental effect on the developing fetus. This is largely due to the fact that the drug, when taken orally, is not absorbed into the systemic circulation, just as when used topically. As a result, the chemical components simply do not reach the fetus.

Despite this, during pregnancy, especially in the early stages, preference is given to the use of suppositories, and only with more extensive indications and serious situations it is better to use tablets inside.

Watch the video about the drug:

Application schemes

The regimens of use and the form of the drug depend on the goals pursued and the general condition of the woman.

Pills

The average dose is 1 tablet 4 times a day. Children are usually prescribed only 2 times a day. The duration of treatment differs. So, it is approximately as follows:

  • with intestinal candidiasis, the remedy should be taken within a week;
  • in case of nail fungus infection, the minimum duration of therapy is 2 - 3 months, until a new nail grows back;
  • if the tablets are used as an adjunct to local treatment, for example, for vulvitis or skin pathologies, the course is on average 2 to 3 weeks.

Candles

Suppositories are used to treat fungal infections of the external and internal genital organs.

Pimafucin (suppositories) in early pregnancy is prescribed one suppository deep into the vagina once a day. It is best to administer the medicine in the supine position, after which it is recommended to remain in a horizontal position for some time so that the dissolved suppository does not leak out. With this in mind, the remedy is usually laid at night.

The average course is from 3 to 6 - 7 days. Depending on the clinical picture, you can extend the treatment up to 2 - 3 weeks or add tablet forms.

Cream

The cream is used for lesions of the skin, nails or for application to the external genital organs, as well as for the treatment of candidiasis in men. The product is applied up to 3 - 4 times a day in a thin layer.

Possible complications and side effects

Despite the fact that the drug is approved during pregnancy, various side reactions and complications can occur during its use.

When taking pimafucin tablets, you may experience nausea, loosening of the stool. However, these minor disorders go away on their own with further use of the remedy.

When using the cream and suppositories, a burning sensation and minor tissue irritation may occur. Such conditions do not require additional treatment and soon disappear on their own.

Pimafucin should not be taken if allergic reactions of any manifestation (rash, edema, etc.) have ever been recorded on the components of the drug.

It is noteworthy that the remedy can be combined with others, since it is not absorbed in the intestines and the surface of the skin, and does not interact with other drugs.

Analogs

There are drugs that also contain 100 mg of natamycin and have the same methods, indications and contraindications for use. These include:

  • Natamycin. Its cost varies from 200 to 400 rubles.
  • Primafungin. Price from 220 rubles for three vaginal suppositories.
  • Ecofucin is also only in the form of candles.

Thus, there are analogues for this drug, but they are not presented in all forms, only pimafucin has a variety (cream, tablets).

Often during pregnancy one has to deal with the manifestations of a candidal infection of the genital organs in a woman. The doctor and the expectant mother always face a choice - to use the medicine effectively or safely.

Pimafucin is a drug that can be safely prescribed even in the early stages of pregnancy and continue taking until the very birth if necessary. Baby and mom will be safe using this medication.