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How to drink duphaston to maintain pregnancy. Information about Duphaston: composition and its positive properties. Infertility and Duphaston

One of the most pressing problems is the problem of miscarriage. The causes of miscarriage are many and varied, but the most common cause is inadequate production of progesterone by the corpus luteum.

Duphaston: application

Currently, in the Russian Federation, to treat the threat of termination and preservation of pregnancy, such medications as micronized progesterone Utrozhestan and dydrogesterone - Duphaston, an analogue of natural plant-derived progesterone, are used.

The prescribed drug Duphaston during pregnancy is safe for both the fetus and the mother. The safety of Dufaston has been proven not only in clinical studies, but also in real medical practice, where it has been widely used for many years.


Duphaston

Role of progesterone in pregnancy

Progesterone - (lat. pro- for, gestation- pregnancy) is a key steroid hormone necessary to prepare for pregnancy, both to maintain the menstrual cycle and to maintain the pregnancy itself. The relative or absolute deficiency of progesterone leads to impaired reproductive function or menstrual cycle. Progesterone deficiency can be eliminated with exogenous progestogens. Currently, they are used to treat various gynecological pathologies, such as infertility, threatened miscarriage or recurrent miscarriage.

During pregnancy, progesterone protects the fetus, which is foreign to the mother's body, from immunological rejection, suppresses the contractile activity of the myometrium by reducing the sensitivity of the myometrium to stimulation with oxytocin, and also prepares the endometrium for implantation.

Duphaston: indications for use

Progesterone deficiency (progesterone deficiency) can have serious consequences:

  • before pregnancy- infertility due to the fact that the endometrium of the uterus is not ready for the attachment of a fertilized egg, endometriosis, dysmenorrhea (pain during menstruation), irregular menstruation;
  • during pregnancy- spontaneous abortion - threatening abortion, habitual miscarriage (loss of pregnancy 2-3 times or more) associated with an established progesterone deficiency.

Luteal phase failure- one of the main causes of miscarriage and menstrual irregularities. Insufficiency of the luteal phase is due not so much to a hormone deficiency, but to a decrease in the sensitivity of the endometrial receptor apparatus to the effects of progesterone. Decreased sensitivity may be associated with damage to the endometrium and mechanical removal of endometrial cells (and, therefore, together with cells of progesterone receptors) during any intrauterine interventions (diagnostic curettage, abortion, frozen pregnancy), infections, etc.

How to take Duphaston during pregnancy

Duphaston is available in tablet form. The tablets are taken orally (orally). The dosage regimen is selected individually depending on the nature and severity of the disease.

Infertility due to insufficiency of the luteal phase: 10 mg per day from the 14th to the 25th day of the cycle. Treatment should be carried out continuously for at least six consecutive cycles. In the first months of pregnancy, it is recommended to continue treatment according to the scheme described for habitual miscarriage (10 mg 2 times a day).

Threatened abortion: 40 mg once, then 10 mg every 8 hours until symptoms disappear.

Habitual miscarriage: 10 mg 2 times a day until the 20th week of pregnancy, with a gradual dose reduction.

Duphaston during pregnancy is taken only as directed by the attending physician. The dosage and duration of the drug is determined strictly individually in each case.

How long does Duphaston take during pregnancy?

In order to prevent miscarriage due to a lack of endogenous progesterone, doctors recommend taking Duphaston until the 16-20th week of pregnancy with the gradual withdrawal of the drug. The period of use of the drug is established by the doctor and depends on the severity of the woman's pathology and on the level of the hormone progesterone, which must be monitored regularly. After the sixteenth to twentieth pregnancy, the placenta synthesizes sufficient levels of progesterone to support the pregnancy.

Reducing the dose of Duphaston... It is necessary to start the abolition of Duphaston during pregnancy gradually, slightly reducing the dosage of the drug. The number of tablets is reduced by ½ to 1 every five to seven days.

An approximate scheme for canceling Duphaston: if you took 1 tab. 2 times a day, then with gradual cancellation:

  • 1/2 t. 3 times a day - 5 days;
  • 1/2 t. 2 times a day - 5 days;
  • 1/2 t. 1 time per day for 5 days.

The duration of drug withdrawal and the dose should be adjusted by the doctor taking into account the condition of the pregnant woman.

Contraindications

  • Individual intolerance to dydrogesterone and other components that make up Duphaston (lactose, hypromellose, corn starch, colloidal silicon dioxide, magnesium stearate).
  • Vaginal bleeding of unknown origin.
  • Liver dysfunctions due to acute or chronic diseases.
  • Galactose intolerance, lactase deficiency.
  • Age up to 18 years, due to the lack of data on efficacy and safety in adolescent girls under 18 years of age.

Carefully Duphaston should be used for conditions that previously appeared or worsened during a previous pregnancy or previous hormone intake: herpes during pregnancy, severe itching.

Side effect

Most common: headache, nausea, breast tenderness / tenderness.

May cause mild drowsiness and / or dizziness, especially in the first hours of admission, so care should be taken when driving, but in general it is well tolerated by women.

Safety of the drug Duphaston during pregnancy

Duphaston does NOT have androgenic or estrogenic properties. Unlike a number of other gestagens, it does not cause masculinization of the genital organs of the female fetus and feminization of the genital organs of the male fetus. That is, the fear that when using Duphaston, a female fetus will develop primary and secondary sexual characteristics of a male, and vice versa, is groundless.

Duphaston very rarely leads to weight gain, does not lead to seborrhea, coarsening of the voice, the appearance of acne (acne) and hirsutism (excess hair growth on the body and face) in women, does not significantly affect blood clotting.

Of course, one of the main destinations of any woman is motherhood. It is the birth of a baby that is a great happiness for every family.

However, there are situations when a woman cannot get pregnant or bear a healthy baby. It is good that at such moments, modern medicine allows you to eliminate a large number of obstacles on the way to successful fertilization and future childbirth.

If a woman has a hormonal imbalance, which is the main cause of infertility, miscarriages and other pathologies, then they come to the rescue. To solve these problems, the hormonal agent Duphaston has earned a good reputation.

What is Duphaston?

Duphaston Is a medication in tablets used to treat diseases of the female reproductive system. It is completely safe for women. The drug has practically no side effects on the body.

How to get rid of a female disease? Irina Kravtsova shared her story of recovering from thrush in 14 days. In her blog, she told what drugs she was taking, whether traditional medicine was effective, what helped and what did not.

This medication is hormonal, and you can drink it only as directed by the attending physician, after conducting a lot of examinations and various tests for the hormonal background of the body. The doctor will create an individual map, tell you how to use the medication indicating the doses and duration of admission, and also tell you how to properly end the use of Duphaston.

Unauthorized use or cancellation of the use of such a medicine is strictly prohibited - this can provoke unpredictable complications.

The active ingredient is dydrogesterone, a hormone synthesized by an artificial method, which is an analogue of progesterone, which is generated in the human body. The natural hormone is often referred to as the "pregnancy" hormone due to the fact that it is he who oversees the reproductive function in the female body.

Thanks to artificially obtained dydrogesterone, it was possible to eliminate almost all the side effects of natural hormonal drugs, for example:

  • blood clotting imbalance;
  • glucocorticoid action;
  • plastic metabolism (anabolic effect);
  • estrogen activity;
  • activity of thermogenics;
  • androgenic effect

Duphaston received a lot of approving reviews from doctors and patients.

Instructions for the use of Dufaston

It is necessary to use Duphaston during pregnancy only as directed by a specialist who will determine an individual intake regimen.

Rules for taking Dufaston

Taking Duphaston tablets, you must adhere to the following general rules:

  1. The drug must be used at regular intervals. Normally, if you take a pill at 7 o'clock in the morning, then the next time you need to drink it at 7 o'clock in the evening.
  2. If you miss a pill, you must wait for the next reception time, so as not to break the frequency.
  3. It is necessary to finish taking Duphaston after being convinced that a pregnancy has not occurred. To do this, you can take a pregnancy test or blood for hCG if there is a delay in menstruation.
  4. In case of pregnancy, it is strictly forbidden to finish drinking it. It is necessary to consult a doctor if the patient has drunk Dufaston.
  5. Cancellation of Dufaston is carried out in stages, according to the plan, which was selected by the attending gynecologist.

What are they prescribed for?

Duphaston is prescribed for women during maintenance or replacement therapy, when a lack of progesterone is detected, on which conception, gestation, and childbirth itself directly depend. Relaxation of the uterus and its premature contraction are important effects from the work of progesterone

The lack of a sufficient amount of this hormone at the stage of pregnancy can lead to the following consequences:

With the ailments and dysfunctions described above, experts often prescribe Duphaston.

Prescribing a medication when planning conception

With the help of the hormonal medication Duphaston in the female body, a favorable background is created for the fertilization of the egg, the introduction of the embryo into the uterus and the subsequent development of the fetus.

When planning the conception of a child, these pills must again be prescribed by a specialist, since there is no universal scenario for taking them.

Basically, for the conception of a child, the drug is prescribed to be taken on the next day after ovulation and taken until the onset of menstruation. It is recommended to cancel the drug only when passing the test or at the initial stage of menstruation to make sure that there is no pregnancy.

The fact is that a sharp decrease in progesterone in the blood can worsen the nutrition of the embryo or its complete rejection. Taking this medication at the planning stage of the child with a detected imbalance in the hormonal background, Duphaston has a greater effect in the future during pregnancy.

The full effect of taking Duphaston for conceiving a fetus occurs after 6 months. When the drug has been taken for more than a year to no avail, it is recommended to consult a doctor in order to change the tactics of treatment, further examinations or prescribe other drugs, to find an effective substitute for the drug.

Refuse to take this medication, in cases of its appointment for prophylaxis without additional examinations. It is worth finding another gynecologist!

Duphaston in early pregnancy

In the first stage of pregnancy, Duphaston tablets are used when insufficient is generated in the woman's ovaries.

This medication has a selective effect on the endometrium, thereby maintaining it in the state necessary for the development of the embryo, and also keeps the contractions of the smooth muscles of the uterus, thereby preventing possible miscarriage.

Thus, this drug can fully replace the natural hormone at an early stage of pregnancy.

The drug does not have a negative reaction to the embryo and the mother's body during this period of pregnancy. Usually prescribed in the first and second trimester of pregnancy to preserve it.

As soon as the signs of miscarriage have disappeared, then it is worth taking the drug in the same doses for about a week, after which you switch to a lower dose to maintain the hormone level. It is strictly forbidden to abruptly cancel the medication intake, as this can lead to an abortion.

Prescribing the drug during pregnancy

At later stages of pregnancy, namely, starting from the third trimester of fetal maturation, the drug should be used carefully, because at these times it can cause liver dysfunction.

At this stage, Duphaston tablets cope with the following tasks:


Also, during pregnancy, a medication can be prescribed for endometritis in the chronic stage.

A distinctive feature of this disease is the increased fighting ability of the immune system, which considers the embryo as a foreign body and tries to quickly remove it from the female body.

This medication blocks this factor, bringing the immune system back to normal, thereby eliminating the possibility of miscarriage.

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Reception with endometriosis

It is known that one of the main causes of endometriosis is an increased level of estrogen in a woman's body. As a result, it is worth using Duphaston, which, with endometriosis, lowers the level of estrogen and stabilizes the cumulative level of hormones.

The following characteristic features of the use of a medication for the treatment of this disease can be distinguished:

  1. Dydrogesterone mainly affects the uterine mucosa, suppressing the proliferation of endometrial receptors.
  2. Since the menstrual period is not in a depressing stage, the likelihood of conceiving a child remains.
  3. Duphaston reduces the tone and contractile capacity of the smooth muscles of the uterus, which in the early stages of pregnancy reduces the threat of spontaneous abortion.
  4. Thanks to this drug, pain syndrome decreases or disappears without a trace. This is due to the fact that there is a decrease in the generation of prostaglandins, which in turn cause a sharp narrowing and constriction of the blood vessels of the circulatory system.
  5. Duphaston significantly reduces the risk of degeneration of cells with pathology into cancerous neoplasms. According to numerous reviews of patients who took Duphaston, the menstrual cycle is transferred more calmly and with less pain, it stops pulling the lower abdomen.

How to use hormonal pills for endometriosis, it is imperative to specify with the treating specialist, but, by and large, the instruction looks like this:

  1. Duphaston is taken twice a day, at the same time of day. For example, at 8 am and 8 pm.
  2. The duration of admission is individual in each case, but usually ranges from 5-6 to 20 days.
  3. Sometimes the drug is taken for a long time without interruption from 6 to 9 months, which allows the disease to atrophy (reverse development).

As with other reasons for taking Duphaston, with endometriosis, it must also be used according to the recommendations of the attending specialist, and not self-medicate.

Infertility and Duphaston

  • With childlessness in a woman, which is determined by luteal insufficiency of the phase of the menstrual cycle, Duphaston is taken from 14 to 25 days of the cycle. The minimum duration of the drug use is 6 months, after which it is necessary to stop taking it. After the onset of pregnancy, the drug is used for about 16-20 weeks, then you need to stop taking the drug.
  • With hormonal disorders
  • Duphaston can be used to diagnose secondary amenorrhea and dysfunctional uterine bleeding. In case of hormonal imbalances, carry out replacement therapy in women with disorders caused by menopause with an intact uterus.

Stories from our readers!
"The gynecologist advised me to take natural remedies. They opted for one drug - which helped to cope with hot flashes. It's such a nightmare that sometimes I don't even want to go to work from home, but I have to ... As the appointment began, it became much easier, even felt that there was some kind of internal energy. And I even wanted to have sexual relations with my husband again, otherwise it was all without much desire. "

How to choose the right dosage?

When dosing the drug Duphaston, you must adhere to the following rules:

  1. With PMS- 10 mg of the drug twice a day from 12 to 28 days of the cycle.
  2. For menstrual disorders- 10 mg of the drug twice a day from 11 to 25 days of the cycle. The treatment lasts at least 6 cycles.
  3. With endometriosis- the daily dose of the drug can vary from 10 to 30 mg from 5 to 25 days of the cycle or taking it on an ongoing basis.
  4. With infertility- apply the medicine twice a day, 5 mg from the 14th to the 25th day of the cycle. The duration of therapy should not be less than 6 cycles.
  5. With a threatened miscarriage- immediately take 20 mg of the drug, then reduce the intake to 10 mg twice a day (in the morning and in the evening at equal hours). If the threat of miscarriage persists, Duphaston can be taken 5 mg three times a day (every 8 hours). When the symptoms of miscarriage have disappeared, the drug is still taken for about a week. In case of recurrence of symptoms, the drug should be used immediately in the dosage that had the greatest effect on their elimination.
  6. With a habitual miscarriage: a daily dose of 10 mg is divided into 2 doses. The duration of the course can be up to 20 weeks. After the disappearance of the symptoms of miscarriage, Duphaston is gradually canceled.

Who is Dufaston contraindicated for?

There is no destructive contraindication of the active substance of Duphaston for patients with chronic renal failure.

My personal story

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It is scary when women do not know the true cause of their diseases, because problems with the menstrual cycle can be harbingers of serious gynecological diseases!

The norm is a cycle lasting 21-35 days (usually 28 days), accompanied by menstruation lasting 3-7 days with moderate blood loss without clots. Alas, the state of gynecological health of our women is simply catastrophic, every second woman has some kind of problems.

Today we will talk about a new natural remedy that kills pathogenic bacteria and infections, restores immunity, which simply restarts the body and turns on the regeneration of damaged cells and eliminates the cause of diseases ...

Side effects of Duphaston

When using the drug, some side effects may occur:

  • hypersensitivity of the immune system may very rarely appear;
  • single precedents of hemolytic anemia were recorded;
  • the appearance of headaches and migraines;
  • liver dysfunction may begin, expressed by jaundice, pain in the abdomen and general weakness of the body;
  • Quincke's edema was extremely rare;
  • rare manifestation of subcutaneous tissue, urticaria and skin irritation;
  • possibly an increase in the sensitivity of the mammary glands;
  • rarely, when taking, breakthrough bleeding in the reproductive system is likely, which disappear after increasing the dose of the drug;
  • peripheral edema appears extremely rarely (the appearance of excess fluid in the tissues and cavities of the body);
  • general disorders of the body are possible.

If you fix any of the listed side effects, you should immediately contact your doctor to find out if you can stop or continue taking the drug.

Duphaston and alcohol

The manufacturer of the drug in the instructions for the drug indicated its possible negative effect on the liver. Since alcohol also has a negative effect on the liver, taking any medication increases the load on this organ.

The interaction of Duphaston with alcohol, which can have a negative effect on the liver, is a triple load.

Among other things, alcohol changes the enzyme composition of the liver, which can lead to inappropriate effects of this medication.

The reaction to the gastrointestinal tract, if you combine dyufastone and alcohol, is also ambiguous.

The active substance of the drug relaxes the abdominal muscle group, and alcohol is a poison that the human body tries to remove faster.

Adding these two factors together, taking the medicine and alcohol can lead to vomiting or diarrhea, which means the rapid elimination of the active substance of the drug from the body, and this will reduce the entire positive effect of its use to a minimum, and there is simply no point in taking it.

Any kind of alcohol when prescribing a medication to preserve the fetus is categorically contraindicated. Even in the absence of medication to maintain pregnancy, drinking alcohol is prohibited.

Alcohol also has an effect on the blood vessels, they either narrow or expand. This negatively affects the hemodynamics of the organs of the reproductive system, which contributes to hormonal disorders.

With the above negative factors, the compatibility of alcohol and Duphaston, it can be concluded that why drink alcohol if it greatly reduces the effectiveness of the use of this medication.

However, if alcohol consumption cannot be avoided, then you need to limit yourself to one glass of good wine, adding ice or water to it. It should take at least 2 hours from drinking alcohol to taking the medicine.

Dyufaston or Utrozhestan?

Utrozhestan is made from the natural hormone progesterone from plant components.

The resulting substance is almost completely similar to a natural hormone that is produced by a woman's placenta. Thanks to this, the body perfectly assimilates it, as compatible, taking it as true.

The indications for taking Utrozhestan are:

  • infertility caused by hormonal imbalance;
  • risk of miscarriage;
  • hyperandrogenism (increased content of the male sex hormone in the blood) and other pathologies that have arisen against the background of hormonal disruption.

Neither Utrozhestan nor Duphaston inhibit ovulation when taken in a prescribed dosage for therapeutic purposes in the second phase of menstruation. Cancellation of both drugs is carried out gradually, reducing the dose by the date prescribed by the gynecologist. Both drugs also do not have a negative effect on the mother and child, if taken as prescribed by a doctor.

Pros and cons of Duphaston and Utrozhestan

Sometimes women, when faced with the need to take hormonal drugs, as exemplified by Duphaston and Utrozhestan, wonder if they can be different? Is it possible to replace the drug?

At first glance, these two medicines are very similar, but there is a difference. Can you replace the drug? Is it possible to take both drugs at the same time?

Comparing these drugs in composition, one can distinguish a difference in the method of production of the active substance:

  • Utrozhestan is made from plant-based progesterone;
  • Duphaston is made from a synthesized hormone.


Duphaston has fewer harmful effects characteristic of Utrozhestan:

  • frequent dizziness;
  • drowsiness (Utrozhestan has a calming effect);
  • weakness;
  • changes in body weight;
  • nauseating effect.

However, Utrozhestan has two methods of application. The medication can be used orally (with a liquid) and intravaginal (inserted into the vagina) ways.

Duphaston also does not affect the following points:

  1. Ability to drive a motor vehicle (driving with caution is recommended when taking Utrozhestan).
  2. Basal temperature indicators (sufficient doses of Utrozhestan lead to a sharp increase in basal temperature)

Which medication to choose - Utrozhestan or Duphaston - for conceiving a child or during pregnancy is determined purely individually. Sometimes gynecologists prescribe the patient to take two drugs at once.

Terms of sale

Sales in pharmacies are carried out only according to a prescription written in Latin.

Prices for Dufaston

The cost of the medicinal product fluctuates in the range 400-500 rubles per package ... The price of tablets in different cities of Russia will depend on the place of sale, promotions and discounts in pharmacy organizations. For example, in the Ozerki pharmacy, tablets cost about 450 rubles per package.

Release form

Duphaston is available in tablet form for oral administration. Tablets weighing 10 mg coated with excipients.

Storage conditions

It is necessary to store the tablets in a dry place at a temperature not exceeding 30 degrees.

Shelf life

The shelf life of the drug is about 5 years, after which it is prohibited to take it.

This is not a panacea, but the only way to keep the baby or reproduce the conception. It is for this purpose that Duphaston is prescribed during pregnancy.

A woman who is desperate to conceive a child or maintain a pregnancy is ready to take risks. And this risk will be justified by the appearance of the long-awaited baby.

Positive impact is known. But is it worth taking Duphaston if the pregnancy has already occurred? Will he harm the unborn child? Are there any analogues or alternative treatments?

Composition

The main active ingredient is dydrogesterone ( 10 mg in one tablet).

Dydrogesterone- an oral preparation with a selective effect on the uterine mucosa.

This means that dydrogesterone does not render on the body of androgynous effects (the effect is characteristic of male sex hormones - steroids) and does not suppress immunity glucocorticoids.

Additional substances that make up Dufaston:

  • lactose monohydrate;
  • methylhydroxypropylcellulose;
  • corn starch;
  • Opadry Y-1-1000 white dye;
  • colloidal anhydrous silicon dioxide;
  • magnesium stearate.

Release form: biconvex film-coated tablets for internal use. One carton contains a blister with 20 tablets. Country of origin - the Netherlands.

What are they prescribed for?

Reasons why a doctor may prescribe course of taking Duphaston for a pregnant woman:

  • bleeding and daub (pink discharge) in the early stages;
  • dyshormonal type;
  • habitual abortion;
  • habitual miscarriage of the fetus;
  • endometriosis.

How to use

Dydrogesterone is « pregnancy hormone » so it is safe for the fetus. But this no reason to take the drug without a doctor's prescription... remember, that any hormone, one way or another, will "manifest" in the future.

If a woman has a natural pregnancy, she feels great, all changes take place according to the fetal development schedule, then prescribing Dufaston's reception only for "reinsurance" is unacceptable! If you feel that your doctor is incompetent, contact another specialist, or preferably two, and compare their verdicts!

How much is taken at Duphaston and its dosage

V official instructions for use Duphaston is indicated the recommended period of taking the drug during pregnancy:

  • with threatened abortion - 40 mg of dydrogesterone for the starting dose and then 10 mg every 8 hours until the symptoms are completely eliminated (daub, bleeding);
  • with the usual abortion - 10 mg of dydrogesterone 2 times a day until the 20th week of pregnancy, gradually reducing the dose.

Application

In the first trimester Duphaston is prescribed to eliminate the symptoms of abortion. This is the most dangerous period for termination of pregnancy. Therefore, it is very important to support the body with an additional source of progesterone.

In the second and third trimesters the drug is usually not prescribed. Taking it as a preventive measure is strongly discouraged. This is hazardous to health!

Remember three taboos:

  1. Don't try to heal yourself- this can lead to irreversible consequences.
  2. Do not replace the drug with analogues without a doctor's instructions- the treatment will be ineffective.
  3. Do not stop taking the drug without consulting your gynecologist- it will only aggravate the situation.

How to undo correctly

Abrupt withdrawal of the drug is a risk to the fetus. Breakthrough vaginal bleeding is common. Your doctor will tell you how to reduce the dose of Duphaston.

Cancellation of Duphaston can be short (if the “minus 1 tablet” scheme is developed) or it can take a week (if the “minus 0.5 tablet” scheme is adopted). In each individual case, only the dose that will be as harmless as possible for the mother and baby is canceled.

Side effects

The most common side effects of Duphaston are:

  • peripheral edema of the arms and legs (due to the properties of Duphaston, to change the composition of fluids in the body);
  • hives and pruritus (due to the effect of the drug on the liver);
  • and migraines;
  • increased sensitivity of the mammary glands.

Rarely observed:

  • breakthrough bleeding (in this case, the doctor may increase a single dose of the drug);
  • Quincke's edema;
  • hemolytic anemia.

In case of overdose the manifestations of the digestive system (nausea, vomiting) and the endocrine system (increase and) are aggravated. Special antidote is absent, therefore treatment is carried out symptomatically... Also worth n Seek medical attention immediately.

Contraindications

With extreme caution, Duphaston should be taken and prescribed to those women who have experienced itching during a previous pregnancy and taking the drug. This indicates that the drug provokes the development of cholestasis - stagnation - and an increase in the level of bile acids.

Contraindications to taking Duphaston:

  • individual intolerance to the components of the drug;
  • a pronounced reaction to dydrogesterone;
  • strong side effects;
  • congenital Rotor and Dabin-Johnson syndromes.

A drug such as Duphaston is often prescribed during pregnancy. It belongs to the group of hormonal drugs that help maintain the gestation process. Let's consider the drug in detail, highlight the indications for its use, dwell on the features of its use, find out how to drink Duphaston during pregnancy.

Why is Dufaston prescribed during pregnancy?

Not all women expecting the appearance of a baby know why Dufaston is prescribed to pregnant women, and they address this question to the doctor. Doctors note that this medicine is a synthetic analogue of progesterone. The drug is based on dydrogesterone, which in structure and properties is completely similar to the hormone that is synthesized in the female body.

The drug can be prescribed both at the stage and after its onset, for a short period of time. Its active ingredient prepares the endometrium for the next - the introduction of the ovum into the uterine wall. Immediately from this moment, gestation begins. Doctors, appointing Duphaston during pregnancy, pursue the following goals:

  • successful implantation;
  • prevention of spontaneous abortion;
  • preparation of the reproductive system for the gestational process.

Duphaston during early pregnancy

Often, Duphaston during pregnancy, in its early stages, is prescribed to women who have had problems with bearing a child in the past. Habitual miscarriage is a common disorder. Doctors talk about such a violation if 2 or more pregnancies were interrupted at the very beginning. Moreover, their term did not exceed 12 weeks. Duphaston with the onset of pregnancy reduces the likelihood of developing this complication and helps to bear the child.

How to take Duphaston during pregnancy?

Before taking Duphaston, pregnant women need to consult a doctor. He directly knows the features of this gestation, analyzes the anamnesis of the expectant mother. Based on the data obtained, an individual course of therapy is drawn up - the dosage, frequency and duration of drug use are established. In most cases, the drug is taken from 6-7 weeks of pregnancy.

Duphaston dose during pregnancy


It should be noted that the drug is often prescribed even before the onset of conception, at the stage of pregnancy planning. In order to stabilize the hormonal system, a woman who is going to become a mother takes Dufaston for 6 cycles. They drink it from 11 to 25 days (with a menstrual cycle of 28 days). Another regimen of admission is also possible, which is developed by the attending physician individually.

After conception, the expectant mother continues to drink Duphaston during pregnancy. A sharp, one-time withdrawal of the drug is impossible - a decrease in the concentration of the hormone progesterone in the bloodstream can provoke. As for the dosage, its classic option in this period is 1 tablet 2 times a day (20 mg per day).

How much to drink Duphaston during pregnancy?

Taking Duphaston during pregnancy should always be agreed with your doctor. He directly indicates not only the specific dosage, but also the duration of the drug intake. It depends on the degree of violation and its severity. If we talk about the approximate period of drug withdrawal, then this happens by the 20th week of gestation. Some pregnant women stop taking it at 16 weeks, as directed by the doctor.

To determine the need to discontinue the drug or continue taking it, doctors prescribe a laboratory test. It sets the exact concentration of the hormone progesterone in the bloodstream of the expectant mother. The results of the analysis directly determine the further algorithm of actions of the attending physician. In this case, the pregnant woman must strictly follow the medical instructions.

Duphaston - side effects during pregnancy

The use of Duphaston during pregnancy is associated with the possibility of developing side effects. The likelihood of their development increases with non-compliance with the dosages indicated by the doctor, the frequency and duration of drug use. Among the common side effects when using the drug:

  • headache;
  • nausea;
  • dizziness;
  • bloody vaginal discharge;
  • allergic reaction.

If one of these violations occurs, you should consult a doctor. This phenomenon should be the reason for revising the dosage or frequency of use of the drug. As a last resort, they replace it with a similar drug. Use the drug with caution in cases where a course of estrogen therapy was previously carried out (including the use of oral contraceptives). Concomitant use of estrogens and progesterone increases the risk of thrombosis.

Contraindications of Duphaston during pregnancy

Even if there are indications for use, not all expectant mothers can use Dufaston tablets during pregnancy. Because of this, before prescribing the drug, the doctor must carefully analyze the history of the pregnant woman, exclude certain diseases. Among those:

  • Rotor syndrome;
  • diseases of the cardiovascular system;
  • Dabin-Johnson syndrome;
  • diabetes;
  • kidney disease;
  • itchy skin.

How to cancel Duphaston during pregnancy?


Cancellation of Duphaston during pregnancy should be done gradually. The scheme is drawn up individually, and depends on the dosage in which the pregnant woman took the drug. Every day it is reduced by 0.5-1 tablet. For example, if, as prescribed by the doctor, the expectant mother took 3 tablets of medicine every day, then each subsequent day the dose is reduced by 1-0.5 tablets. So they finally stop taking the medicine after 3-6 days. Compliance with the withdrawal scheme established by the doctor excludes the possibility of a sharp decrease in the concentration of progesterone in the blood.

Plays an important role in pregnancy hormone progesterone, which prepares the endometrium of the uterus for implantation of a fertilized egg and contributes to its further development.

Progesterone protects the fetus from possible reactions of the woman's immune system, aimed at rejection of the fetus in the first weeks after fertilization, suppresses the contractive activity of the uterus and controls its normal functioning.

Lack of progesterone production in the first trimester of pregnancy leads to detachment of the ovum, threatening miscarriage and spontaneous abortion. Drug drug Duphaston is a synthetic analogue of progesterone, the use of which helps to maintain the hormone at the optimal level necessary for the normal course of pregnancy.

Can Duphaston be taken during pregnancy?

If an obstetrician-gynecologist appoints a pregnant woman to take Duphaston, then there are objective reasons for this. Indications for the use of the drug in the first trimester is a lack of progesterone, confirmed by laboratory tests.

A lack of hormone may be indicated by bloody discharge from the vagina, pulling pains in the lower abdomen and in the lower back. These conditions are symptoms of threatened miscarriage.

Duphaston therapy is prescribed for women with a history of spontaneous miscarriages caused by hormonal disorders. In this case, the drug is taken from the first weeks of pregnancy to the middle of the second trimester.

When symptoms of threatening abortion appear, the obstetrician-gynecologist prescribes Dufaston urgently, without test results, since laboratory diagnosis of hormonal levels is a long procedure. In this situation, it is important to preserve the pregnancy, especially since the drug does not carry no harm to the fetus... Therefore, it is necessary to take Duphaston according to the testimony of a doctor.

In the early stages

Treatment with Dufaston for women with recurrent miscarriage begins immediately from the moment of pregnancy confirmation and is performed up to 20 weeks. For threatening abortion, progesterone therapy is prescribed from the moment symptoms appear.

Bloody issues in the first trimester of pregnancy, they mainly appear at a period of 4-6 weeks, which are a symptom of detachment of the ovum. The most common cause of detachment is a decreased function of the corpus luteum, due to a lack of progesterone.

The appearance of bloody discharge is usually preceded by pulling pains in the lower abdomen. In these conditions, it is necessary to see an obstetrician-gynecologist, in most cases, treatment with Dufaston will be prescribed.

Numerous medical studies of the effectiveness of Duphaston have proven it positive effect on pregnancy... Many scientists are raising the question of the need to prescribe the drug to all pregnant women from the first day of pregnancy detection, without waiting for the symptoms of complications, in order to prevent involuntary abortions.

Full-fledged progesterone therapy in the first trimester will further avoid pathologies such as fetal-placental insufficiency, intrauterine fetal growth retardation.

How to use

The drug Duphaston is used in obstetric practice in case of habitual miscarriage (if in the past the pregnant woman had 2 or more episodes of miscarriage), threatening abortion, during pregnancy through the IVF procedure.

Threatened abortion- a condition accompanied by increased contractile activity of the uterus. Manifested by a feeling of heaviness, pulling pain in the lower back and lower abdomen.

After a while, a partial detachment of the ovum begins, provoked by uterine contractions. Detachment is indicated by bloody discharge from the vagina.

The drug is available in white tablets with a dosage of 10 mg and has distinctive marks: engraving "S" on one side, and 2 symbols "155" on either side of the scoring on the other side of the tablet. One package contains 20 tablets in a blister.

The dosage and dosage regimen of the drug is due to the specifics of pathological conditions:

  • With threatening miscarriage, bloody discharge, pulling pain in the lower abdomen - 4 tablets once, then 1 tablet three times a day, every 8 hours. The course of treatment is established by the attending physician.
  • During pregnancy through IVF and in women with recurrent miscarriage - 1 tablet every 12 hours until the 20th week of pregnancy (in some cases, the obstetrician-gynecologist adjusts the course of treatment).

Duration and scheme of taking Duphaston in case of a threat of miscarriage, it is established by an obstetrician-gynecologist. If, after a week of taking the medicine, the symptoms disappear, then the dose of the drug is gradually reduced and canceled.

With repeated episodes, treatment is resumed according to the established scheme, after 1 - 2 weeks the dose is reduced to 2 tablets per day and therapy is continued until 16 - 20 weeks of pregnancy, it is by this time that the placenta completes its formation and begins to actively function. Before discontinuing the drug, it is important gradually reduce the dose.

Contraindications for taking Duphaston are: hypersensitivity to the components of the drug, pathological genetically determined increased content of bilirubin in the blood (Dabin-Johnson and Rotor Syndrome).

Duphaston and IVF

The problem of in vitro fertilization is a large number of spontaneous miscarriages. Researchers have shown that the most common reason for the rejection of a fertilized egg from the uterine cavity during IVF is the lack of the luteal phase.

Therefore, it is very important, from the first day of pregnancy confirmation, to take Duphaston's drugs to produce progesterone, which is necessary for carrying a pregnancy.

Why Duphaston didn't help

Unfortunately, Duphaston is not a panacea for all diseases, a reception that always gives a favorable pregnancy outcome. In many cases, the causes of spontaneous miscarriage can be infectious diseases of the mother, proceeding in a latent form, bad habits, stressful situations, malformations of the uterus, artificial termination of pregnancy in the past.

Many experts believe that spontaneous miscarriages in early pregnancy are manifestations natural selection... This hypothesis is confirmed by numerous studies of embryos in which various chromosomal developmental abnormalities have been found.

In some cases, the cause of spotting may be a frozen pregnancy, which in the early stages can only be diagnosed with a hCG analysis in dynamics.