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Ovulation after injection hCG 5000 when. How much after an injection of hCG ovulation occurs. Method of application of HCG - dosages

One of the most popular fertility treatments is ovulation stimulation. It is used for women with problems with the maturation of the egg and the absence of its release from the ovary. To stimulate ovulation, hormonal drugs are used, due to the action of which one or several eggs capable of fertilization are formed in the female body.

In our Reputable Practice, we will test you step by step. Once a gestational carrier has been selected, she should undergo a thorough examination. When all assessments are completed, the treatment cycle can begin. Both the gestational carrier and the donor mother start taking pills and injections to synchronize cycles and prepare for embryo transfer. The donor mother takes the eggs to stimulate her ovaries to produce eggs, while the carrier takes medication to prepare the uterus for implantation.

After embryo transfer, the gestational carrier was asked to reduce excessive physical activity for several days. Once transferred, you will be given and a pregnancy test done in about 10 days. If it is positive, it indicates that implantation has been achieved.

Methods to restore ovulation are selected taking into account the reason for its absence. Achievement of a positive effect from the use of stimulation of ovulation is possible only if the cause that disrupts the ovulatory process is established.

Reasons for the development of anovulation

The reasons provoking the development of anovulation can be physiological and pathological (chronic). Physiological anovulation is considered normal, does not require medical attention and can be observed during the following periods in a woman's life:

The first ultrasound exam to evaluate pregnancy is scheduled approximately 3-4 weeks after transmission. If the pregnancy test is negative, all treatment is suspended and menstruation usually begins in three to ten days. If frozen embryos exist, the process can be started again.

Preimplantation genetic diagnosis

These cells and embryos freeze. The biopsy cells are analyzed and we get a report that tells us if the embryos have a normal number of chromosomes or not. We also learn about fetal sex. This process significantly increases the chances of pregnancy by reducing the frequency of multiple pregnancies and abortions. It also reduces the number of embryos that are retained as only normal ones remain frozen. These embryos without genetic defects are transferred in the future cycle.

Puberty: In adolescent girls, ovulation may not occur for the first two years after menarche;
the period of pregnancy and breastfeeding;
menopause;
period of "rest": 1-2 menstrual cycles per year in women of reproductive age may not ovulate.

Pathological anovulation can be caused by a violation of the structure of organs or diseases of the endocrine system. Most often, the presence of this particular condition is the cause of infertility.

Not all methods offer this procedure. Laparoscopy is a minimally invasive surgical procedure that allows a complete examination and assessment of the female pelvic compartment and abdominal structure. This is an outpatient surgery performed under general anesthesia. The incisions are half a centimeter long so the patient can return home the same day and work after a few days. Pelvic adhesions, endometriosis, tube, ovarian and uterine abnormalities, evidence of past infections, are some of the things we can diagnose with these procedures.

Pathological reasons for the absence of ovulation may lie in the presence of the following conditions:

Dysfunction of the hypothalamus;
oncological diseases of the pituitary gland;
circulatory disorders in the brain;
hyperprolactinemia;
hyperandrogenism;
frequent stress;
injuries of the reproductive system;
inflammatory diseases of the appendages;
obesity;
anorexia;
premature menopause;
(polycystic ovary syndrome, endometriosis, uterine fibroids, etc.);
diseases of the thyroid gland and liver;
while taking hormonal contraceptives.

A large percentage of patients who have all normal fertility tests have pelvic problems. Many times these anomalies can be repaired at the same time. Thus, this operation serves as a diagnosis, helps us plan our next steps, and often increases the chances of pregnancy. Photos are taken before, during and after the operation. Most patients are discharged and can return home after the procedure.

Hysteroscopy is an outpatient surgical procedure performed under anesthesia. A 4-6 mm chamber is inserted behind the cervix to enter the uterine cavity. Fine instruments such as tweezers and scissors are used to correct abnormalities such as polyps, fibroids, scars, and septa. Usually these anomalies can be corrected in one session without incisions. Typically, patients can return to work the next day. Most patients are discharged after a couple of hours.

Diagnosis of anovulation

To diagnose anovulation, it is not enough to draw up a basal temperature graph, since this method is not sufficiently reliable. More informative methods of detecting this pathology are: ultrasound, carried out in dynamics over several menstrual cycles, as well as analyzes that allow you to determine the level of certain sex hormones.

Reversal of tubal ligation

To be able to perform this procedure, it is important that your tubes are blocked, but not destroyed. We need at least 4-5 centimeters of a regular horn to use. It's also important that your partner has a normal sperm test so you can get pregnant after surgery. The operation itself takes about two hours. The incision measures 5-2 inches and is located in the pubic area covered by the "bikini". The patient is discharged the same day and it takes about two weeks to recover and return to daily life.

Tests for the content of hormones in the blood

Stimulation of ovulation is not prescribed if there are abnormalities in the parameters of thyroid hormones, prolactin and male sex hormones in the blood.

Ultrasonic monitoring

In order to confirm or exclude the absence of ovulation, it is necessary to conduct multiple ultrasound examinations during the entire menstrual cycle.

Stages of ovulation stimulation

The chances of pregnancy depend on the type of tubal ligation, the woman's age, other female factors, and the man's sperm examination. However, since the middle of the last century, some weight management clinics have also introduced the substance as a weight loss aid. In recent years, this substance has increased its popularity for this purpose and is usually administered as injections or sublingual drops.

History as a Weight Loss Assistant

This hormone is auxiliary in the production of its hormone compounding progesterone, which dilates the uterus and helps nourish the fetus. While studying pregnant women in India, he realized that those who were in a calorie deficit lost fat instead of muscle. After a full physical examination and pre-detoxification for detoxification, the patient receives daily injections or administers the same number of days himself as the protocol lasts. The patient also adheres to a strict, extremely low calorie diet for the rest of the program, followed by a maintenance high calorie diet.

If the cycle is 28 days, the first ultrasound is scheduled 8-10 days after the last menstruation has ended. Then the study is repeated at intervals of 2-3 days and until ovulation or the beginning of the next menstruation.

Stages of ovulation stimulation

Stimulation with clostilbelite begins on the fifth day of the menstrual cycle, with gonadotropins on the second. The timing of the beginning and duration of taking drugs is determined by the attending physician in accordance with the state of the woman's uterus and ovaries.

The patient must then stop the protocol, but must continue to follow a low calorie diet for at least three weeks. However, the injections themselves last for about three days each. This hormone begins to be produced immediately when the fertilized egg starts to run.

Although a pregnancy test can be done before this time, the chances of getting a false positive result are extremely high if you decide to take advantage of your chances. With this in mind, there is no reason why he should not have a pregnancy test around 12 days.

The first ultrasound examination is performed a few days after the start of the ovulation stimulation procedure. Then ultrasound is repeated every 2-3 days until the follicles reach a size of at least 20 mm. After that, the woman is given an injection of hCG (at a dosage of 5000 to 10000 IU), which starts the ovulation process and prevents follicular regression and the risk of follicular cyst formation.

An injection of hCG is an injection of a hormonal drug with the main active substance - human chorionic gonadotropin: rot, prophasi, horagon, humegon, menogon, choriogonin, etc. the body and its activity increases.

The doctor selects the dosage of the hCG drug in each individual case in accordance with the hormone indicators, the size of the follicles and a number of other equally important factors. An excess amount of chorionic gonadotropin can provoke the development of ovarian hyperstimulation syndrome.

An injection of hCG (human chorionic gonadotropin) triggers the onset of ovulation, which usually begins 24-36 hours after injection. The release of the egg is recorded using ultrasound, after which the woman is assigned additional support for the ovaries (corpus luteum) in the form of injections of urozhestan or progesterone.

The term and frequency of sexual intercourse or artificial insemination during ovulation stimulation is prescribed by the doctor individually, depending on the results of the man's spermogram. With good indicators of the quality and quantity of sperm, it is recommended to have intercourse every day, or every other day, starting from the moment when the woman was injected with hCG and before the corpus luteum is formed.

What is hCG injection

The main factor affecting a woman's ability to become a mother is the presence of ovulation - the process of the release of mature eggs from the follicles and subsequent movement through the fallopian tubes, which determines the readiness for fertilization. Sometimes, for one reason or another, a malfunction occurs in the body, as a result of which rupture of the membrane (follicle) does not occur.

The success of conception largely depends on the level of the human chorionic gonadotropin hormone in the woman's blood, the effect of which on the corpus luteum continues until the fertilized egg is attached to the uterine wall. In some cases, there is a need for the artificial administration of human gonadotropin (HCG injection).

In what cases is an injection of hCG indicated?

An injection of hCG can be prescribed to women in the following cases:

In the absence of ovulation: an injection of hCG stimulates the release of the egg and prevents the reverse development of follicles (atresia). Unexploded follicles can regress, shrinking and forming follicular cysts;
to preserve the vital activity of the corpus luteum: an injection of hCG helps to maintain the state of the corpus luteum before the "transfer" of these duties to the placenta;
for the normal formation of the placenta and maintenance of its functions: when inhibiting the development of the placenta;
with the inability to maintain pregnancy by the female body and the presence of miscarriages in the anamnesis;
if there is a risk of termination of pregnancy;
when planning in vitro fertilization.

HCG injection: contraindications to the injection

An injection of hCG is not prescribed for women suffering from the following pathologies:

Malignant tumors of the ovaries;
a pituitary tumor;
a predisposition to the formation of blood clots in blood vessels;
violation of the patency of the fallopian tubes;
hypothyroidism (insufficient amount of thyroid hormones);
individual intolerance to one or another component of the drug to stimulate ovulation;
with early menopause;
during breastfeeding.

Pregnancy after hCG injection

An injection of hCG can cause a false positive result if a pregnancy test is performed earlier than 14 days after ovulation. This is due to the fact that these tests are based on determining the level of hCG, which is an indicator of the onset of conception, and the artificial administration of this hormone for some time increases its amount in the blood. A more reliable way is dynamic monitoring of hCG, the level of which in pregnant women is constantly increasing until the end of the first semester. At the beginning of the second semester, it gradually decreases to a certain level, which remains unchanged until the end of the pregnancy.

HCG is a hormone that is released into a woman's bloodstream immediately after the ovum is attached to the uterus.

The level of this substance in the blood is constantly increasing, with its help you can find out if everything is fine with the fetus. But this hormone is prescribed when planning conception, so many women are interested in the question of whom the hCG injection helped to get pregnant.

How does the hCG shot work?

Usually, this injection is prescribed only once when planning a pregnancy. This hormone promotes the rupture of the dominant follicle and stimulates ovulation. This medication is prescribed only after the woman takes hormones for the growth of the dominant follicle.

Every 2 days, the follicle is monitored, and when it reaches the desired size, hCG is injected. After administration of the drug, ovulation occurs in 12-36 hours. It is during this period that you need to have sex with natural conception or inject sperm by insemination. Reviews indicate that the injection helps to get pregnant.

When is an injection of hCG prescribed?


There are two options for administering the hormone:

  • stimulation of ovulation with "Klostilbegit";
  • with polycystic ovary, when the follicle grows, but does not burst, but develops into a cyst.

Therefore, an injection of hCG is prescribed for anovulatory cycles, when the egg does not mature. Stimulation is carried out with "Klostilbegit" or "Clomid". On the 14-20th day of the cycle, the hCG hormone is administered. In insemination, sperm is injected only after confirmation of follicle rupture.

The hCG hormone helps to become pregnant and maintain pregnancy. With the artificial induction of ovulation after the administration of chorionic gonadotropin, progesterone is prescribed. Usually it is the drug "Utrozhestan" or "Duphaston". They loosen the endometrium and promote the attachment of the ovum.

Indications for the appointment of hCG:

  • anovulation;
  • insufficiency of the corpus luteum during pregnancy;
  • habitual abortion;
  • risk of miscarriage.

When can a post-injection pregnancy test be done?


It is worth considering that pregnancy test strips react to this hormone. Therefore, before your expected date of your period, you will receive false positive results. After only a few days of delay, it makes sense to do the test.

If you do not have enough patience, and you want to find out about the onset of pregnancy sooner, then donate blood for hCG. By the amount of the hormone in the laboratory, they will be able to judge the absence or occurrence of pregnancy.

When does it make no sense to inject hCG?


This injection is not given at random. It must be done on a specific day of the cycle when the follicle is fully ripe. If the drug is injected earlier, ovulation will occur, but you will receive an underdeveloped egg that cannot develop into pregnancy.

Therefore, the substance is injected only with constant folliculometry for ultrasound. If you have not been injected with drugs to stimulate the growth of the dominant follicle, then the injection is also useless, since there will be nothing to rupture due to the absence of the “main” follicle.

How to determine that pregnancy is developing, according to the level of hCG?


This hormone is included in the mandatory screening for pregnant women. The concentration of this substance is used to judge the health of the fetus. At 14-18 weeks, the pregnant woman donates blood for hCG. If it is reduced, then there is a threat of miscarriage or the presence of pathologies in the fetus.

What to do if hCG is low during pregnancy?


If during the tests it turned out that the concentration of this substance is small, the administration of the hormone by injections is prescribed to preserve the embryo. The fact is that this substance controls the release of progestins and estrogens into the blood. If there are more or less of these hormones, there is a threat of miscarriage. In addition, chorionic gonadotropin is prescribed in case of insufficiency of the corpus luteum, which supplies the ovum with useful substances.

An increased concentration of hCG indicates:

  • about multiple pregnancies;
  • about maternal diabetes mellitus;
  • about taking progestins;
  • Down syndrome in the fetus;
  • about the incorrectly established period of pregnancy.

Therefore, if you are taking "Duphaston" or "Utrozhestan" with a threat of miscarriage, tell the laboratory about it. Usually, it is not the concentration of hCG itself that is analyzed, but its relation to AFP and estriol. Based on the data obtained, a risk diagram for the fetus of genetic defects is plotted, since an increased hormone value is an indication for the analysis of amniotic fluid, the collection of which is carried out by puncturing the mother's abdomen. This increases the risk of infection and miscarriage.

HCG injection is an injection of hormonal drugs such as Menogon, Horagon, Pregnil, Choriogonin and others. Their active ingredient is human chorionic gonadotropin (hCG), which helps restore ovulation.

An injection of hCG with the introduction of these hormonal drugs helps to stimulate the ovulation process. These drugs increase the hormonal activity of the corpus luteum through the administration of hCG. To stimulate ovulation, the dosage of the hCG hormone is 5000-10000 IU. If the doctor plans to maintain pregnancy, the dosage should be 1000-3000 IU. In each case, the selection of the dosage is carried out individually, taking into account the concentration of hormones in the body, the size of the follicle, and so on.

HCG includes two subunits - alpha and beta. The beta subunit is at the heart of the pregnancy test. Beta hCG in the first weeks of pregnancy begins to be produced in the female body, and at 7-11 weeks, its concentration increases several thousand times.

The main factor affecting a woman's ability to become pregnant is ovulation. This is the process of the release of an egg from the ovary into the fallopian tube due to the rupture of a mature follicle for its further fertilization and transportation through the genital tract. Situations often arise when the rupture of the follicle does not occur.

The hormone gonadotropin is responsible for conception and the normal course of pregnancy. It stimulates ovulation in women and promotes the hormonal activity of the corpus luteum until the egg is attached to the uterus.

In cases where ovulation does not occur in the female body for any reason, hormonal stimulation is performed with an injection. Such a procedure is prescribed for women in whose ovaries full-fledged eggs do not mature.

Indications

The procedure is effective in eliminating the following conditions in a woman's body:

1. Dysmenorrhea - a pathological condition characterized by severe pain during menstruation. Other symptoms may also occur: dizziness, weakness, nausea, vomiting, bloating, fainting, and others. 2. Dysfunction of the ovaries. 3. Anovulatory infertility. 4. Threat of spontaneous miscarriage. 5. Deficiency of the corpus luteum. 6. Incorrect formation of the placenta. 7. Inability of the female body to bear the fetus. 8. Preparing for IVF.

This procedure can be used with assisted reproductive techniques as an additional tool.

Men are prescribed for:

1. Hypogenitalism - a significant decrease in the functions of the sex glands and their underdevelopment. 2. Pituitary dwarfism (dwarfism) - delayed growth and development. 3. Sexual infantilism - a delay in the development of the body, manifested in the underdevelopment of the organs of the reproductive system. 4. Genetic disorders.

Contraindications

The use of chorionic gonadotropin injections is contraindicated in:

1. Early menopause. 2. During lactation. 3. During the course of the tumor process in the ovaries and pituitary gland. 4. Obstruction of the fallopian tubes. 5. Thrombophlebitis. 6. Hyperthyroidism. 7. Individual intolerance to the drug. 8. Diseases of the adrenal glands.

HCG injection during anovulation

The following factors can lead to anovulation:

  • dysfunction of the hypothalamus;
  • pituitary neoplasms;
  • stress;
  • violation of the blood supply to the brain;
  • inflammatory diseases of the reproductive system;
  • genital trauma;
  • premature menopause;
  • obesity;
  • anorexia;
  • liver disease;
  • disorders of the thyroid gland;
  • taking hormonal contraceptives;
  • some medicines.

Before proceeding with the stimulation of ovulation, it is necessary to establish the true reason for its absence. For this, patients are prescribed a number of tests, ultrasound. It is also necessary to regularly measure basal temperature. The research results will make it possible to determine the need for the procedure. In some cases, normalizing thyroid hormone levels, for example, can help the natural ovulation recovery process. It is necessary to carry out regular ultrasound in order to monitor the development of follicles.

The initial ultrasound scan is done 8-10 days after the end of menstruation. Then every 2-3 days until the fact of ovulation or the next menstruation is established. According to the research results, an injection of hCG can be prescribed, which stimulates the ovulation process and prevents the formation of follicular cysts.

Typically, after injection, ovulation occurs within 24-36 hours. It is confirmed by ultrasound results. In some cases, ovulation may take a longer time or not at all.

After confirmation of ovulation, injections of uterine or progesterone are given, which further "maintain" the corpus luteum.

When stimulating ovulation, the doctor, on the basis of spermogram indicators, determines the frequency, timing of sexual intercourse and inseminations.

After an injection of hCG, a pregnancy test is carried out no earlier than two weeks after the onset of ovulation. Test results before this expiration date may give false positive results.

HCG injection during pregnancy

During pregnancy, this procedure is prescribed in cases of a low level of chorionic gonadotropin in the body for the possibility of further maintaining the pregnancy. A low concentration of the hormone may be due to early pregnancy. In this case, before prescribing an injection, the doctor directs the patient to re-take tests in order to confirm the low level of the hormone.

Pregnancy after taking an HCG injection

After the hCG injection has been performed, it is recommended to do a pregnancy test no earlier than two weeks later. If you take an analysis for hCG earlier than 2 weeks later, then its result may be false-positive. Therefore, after an injection of hCG, the level of this hormone should be determined over time. Starting from the moment of conception, the level of this hormonal substance doubles every few days. The maximum values ​​of hCG are detected at the end of the first trimester. After that, its level begins to gradually decrease.

If the concentration of the hormone in the blood is 20% or more below normal, then this may indicate a number of serious disorders in the body:

  • chronic placental insufficiency - dysfunction of the placenta, leading to insufficient oxygen supply to the fetus and a possible delay in its development;
  • ectopic pregnancy that develops outside the uterus - in the fallopian tube (99% of cases), abdominal cavity, ovaries. Such a pregnancy poses a great threat to a woman's life;
  • frozen pregnancy - the termination of the development of the fetus and its further death;
  • the threat of miscarriage.

Side effects

Side effects can include:

  • ovarian hyperstimulation syndrome - a condition of the female body characterized by a too strong ovarian reaction to the drug;
  • hydrothorax - the process of fluid accumulation in the pleural cavity;
  • ascites - a disease characterized by the accumulation of large volumes of fluid in the abdominal cavity;
  • thromboembolism is an acute blockage of a blood vessel by a thrombus that has broken off from its place of formation and subsequently entered the bloodstream. This process often ends with ischemic infarction;
  • the formation of cysts.

Procedure

There are standard dosages for chorionic gonadotropin injections:

  • in order to stimulate ovulation, a single dose of chorionic gonadotropin 5000 or 10000 IU is prescribed;
  • in the case of stimulation of the corpus luteum, chorionic gonadotropin 1500 or 5000 IU is used;
  • to stimulate superovulation during reproductive measures, chorionic gonadotropin 10,000 IU is prescribed once. After 34-36 hours, the egg is taken;
  • with habitual miscarriage or the threat of miscarriage, a woman is prescribed an injection of hCG to maintain pregnancy, starting the course no later than the 8th week of pregnancy and continue to be administered until the 14th week inclusive. At the first injection, chorionic gonadotropin 10,000 IU is administered. Then continue injections of the drug twice a week at a dosage of 5000 IU;
  • this procedure gives good results in case of delayed puberty in boys. In the course of treatment, injections of chorionic gonadotropin are used at a dosage of 3000-5000 IU per week for three months;
  • with delayed sexual development in men, HCG injections are prescribed at a dosage of 500, 1000, 1500 and 2000 IU per day for 1.5-3 months;
  • with hypogonadotropic hypogonadism, chorionic gonadotropin 1500-6000 IU is used as a treatment once a week in combination with menotropins;
  • in the case of cryptorchidism, boys under 6 years of age are prescribed chorionic gonadotropin 500-1000 IU for six weeks, two injections per week. Children over 6 years old are injected with the drug at a dosage of 1500 IU.

The drugs are administered to the patient intramuscularly. This procedure can be done in special medical institutions, or independently, if the woman has the skills to do intramuscular injections correctly. Such a need often arises in patients due to a long course of treatment.

The doctor determines the dosage of the drug individually for each patient.

In the pharmacy, you can find the drug in the following dosages:

  • chorionic gonadotropin 500 units;
  • HCG 1000 units;
  • HCG 1500 units;
  • HCG 5000 units;
  • HCG 10,000 units

It is released in the form of a solution for injection.

Most women planning a pregnancy know that hCG is a hormone that begins to be produced after the fertilization of an egg. But don't be surprised if you've heard about the hCG injection. It is done at the planning stage of pregnancy for women suffering from anovulation.

Indications

In the natural cycle, a hormone known as hCG is only produced in the body after conception. But for the fertilization of the egg, it is necessary that the mature follicle burst. For some women, this process is disrupted. As a result, pregnancy does not occur because the egg cannot leave the ovary.

An injection of hCG is prescribed, as a rule, in order to stimulate the onset of ovulation. This can be done after the doctor sees the dominant follicle on the ultrasound. It should be about 20 mm. In this case, after the injection, he will be able to grow a little more and burst.

But it is worth knowing that you cannot prescribe such treatment yourself. Everything should be carried out under the supervision of a physician. The specialist will also need to find the most appropriate dosage for you.

Important information

It is worth knowing that not everyone ovulates after an injection of hCG. In some, the dominant follicle continues to grow until it turns into a cyst. It should also be understood that this is not a treatment for anovulation. The injection can simply help the body grow the dominant follicle and release it. The stimulation performed will not be able to restore ovulation in other menstrual cycles.

It is also important to understand that the diagnosis of anovulation should be made by ultrasound. They start talking about him when, for several cycles in a row, a woman has not released an egg. You can not prescribe an injection of hCG based only on the data from the basal temperature charts.

In addition, it is advisable to check the hormonal background before stimulation. Sometimes it is enough to undergo a course of treatment in order to restore reproductive function. They check female and male hormones, evaluate the work of the thyroid gland. If violations have been identified, then they need to be corrected. Indeed, in case of serious problems, even the use of injections of the hormone may be ineffective.

Stimulation process

It is important to understand that any intervention in the natural processes taking place in the body must be carried out under the supervision of a physician. It is necessary that only the attending gynecologist prescribes an injection of hCG for ovulation. He must also monitor the patient's condition and monitor the body's response to the specified drug. Before the appointment of stimulation, the specialist must assess the dynamics of the growth of follicles, endometrium, and predict the onset of ovulation.

The process of performing the procedure and monitoring will depend on whether you are prescribed only an injection of hCG, or the doctor advises to use drugs that promote follicular growth. It can be such means as "Puregon", "Menogon", "Klostilbegit".

Regardless of how exactly it was possible to achieve the growth and maturation of follicles, hCG (injection) is prescribed. The instruction for such drugs allows you to find out that ovulation should occur no later than 36 hours after the injection. The doctor can prescribe the drug "Horagon", "Pregnil", "Gonacor", "Profazi", in pharmacies you can also find the usual ampoules "Chorionic Gonadtropin". The dosage (usually 5 or 10 thousand units) is also selected by the gynecologist.

Further actions

After the doctor saw a mature follicle on an ultrasound scan and prescribed an injection of hCG, it must be confirmed that it was able to burst and the egg was released. Gynecologists recommend having intercourse every other day, subject to natural conception. If artificial insemination is necessary, it is usually done daily. It is advisable to try to conceive a child in the period after the HCG injection and until the corpus luteum becomes visible on the ultrasound. It indicates that ovulation has already passed.

After this, additional stimulation of the corpus luteum is prescribed. If the egg is fertilized and the pregnancy occurs, progesterone medications will help support its development.

They should not be prescribed for the average 14-16 day of the cycle, as many domestic gynecologists recommend, but after the onset of ovulation has been confirmed. As such supporting agents, "Utrozhestan" or "Duphaston" are prescribed.

How to inject

Everyone who is prescribed an injection of hCG is interested in how and when they need to be done. Of course, you can go to a reproductive medicine clinic (if stimulation is done in the IVF protocol) or to a gynecological treatment room.

But many people still inject themselves at home on their own. These drugs, regardless of the trade name, are produced in dry form. They must be diluted with a special solvent, and then an intramuscular injection of hCG is given. Reviews of women who stimulate ovulation with these funds indicate that this procedure is unpleasant, but tolerable. The injections are well tolerated, they are practically painless.

The drug can be injected into the gluteus muscle or the front of the thigh. It is done once before ovulation. But in some cases (as a rule, with artificial insemination), injections are repeated several times to support the work of the corpus luteum.

Selected dosages

You should not prescribe a hormone on your own without a doctor's recommendation. Also, do not prick it if the mature follicle is not yet visualized on the ultrasound. After all, ovulation after an injection of hCG can occur only when the body is ready for it. The hormone is designed to stimulate this process.

If ovulation has occurred, and this was confirmed by an ultrasound scan, then the doctor may prescribe stimulation of the corpus luteum function. For these purposes, injections are prescribed 3-6-9 days after the egg is released. HCG is used in these cases with a dosage of 1.5 or 5 thousand units.

With the usual miscarriage, women are given injections of the indicated drug as early as possible and continue this therapy for up to 14 weeks. Treatment begins with an injection of 10 thousand units. - this dosage is administered on the first day of therapy. In the future, pregnancy support is done as follows: twice a week, 5 thousand units are injected.

Possible side effects and contraindications

When prescribing hCG injections, it is important to ensure that ovulation occurs. In some cases, it happens that the effect of ovarian hyperstimulation occurs. In this case, the follicle does not burst, but develops into a cyst. Other side effects are also possible:

Thromboembolism;

Diarrhea, nausea;

Hydrothorax;

Gynecomastia.

In addition, some complain about the soreness of the injection site, the appearance of a rash in this area, soreness of the mammary glands, the onset of fever and generalized rash. But, despite the possible complications, many agree to such injections. After all, there is a high probability that pregnancy will occur after an injection of hCG.

Do not prescribe it in case of hypersensitivity to human gonadotropin or to other components of the drug, and in cases where there are tumors whose growth depends on hormones. It can be cancer of the ovaries, uterus, or breast in women. Even if the diagnosis has not yet been established, but the doctor suspects oncology, then HCG injections must be abandoned.

Scope of application

Regardless of the trade name, all hCG preparations act according to the same principle. They stimulate the production of sex hormones. It should be noted that hCG is prescribed not only for the treatment of anovulation.

It is also recommended to use it for chronic miscarriage, the threat of miscarriage and ovarian dysfunction. In some cases, this drug is also prescribed for men. As a rule, it is used to correct genetic disorders. It is prescribed for delayed puberty, which was caused by the insufficiency of the gonadotropic function of the pituitary gland. It is also used for cryptorchidism. The exception is those cases when the disease is caused by an incorrect position of the testicles or a hernia in the groin.

Chorionic gonadotropin is a unique hormone that allows the embryo to develop and gives a woman the chance to become a mother. It is produced by the tissues of the chorion - the fetal membrane immediately after the fertilized egg descends into the uterine cavity and is fixed there. A special drug with the same name is also a chance to experience the joy of motherhood for those who have problems with conception. How the tool is used and what results it gives, we will tell you in this article.


What is it - a drug and analogues

"Chorionic gonadotropin" is a medicine that is obtained from the urine of pregnant women. The hormone enters the secreted fluid from the blood, which in turn is enriched with this substance during pregnancy. The hormonal substance is excreted almost unchanged, which is why it is so easily extracted from the urine of expectant mothers.

In our country, the medicine can be purchased both locally, Russian-made, and its imported counterparts - "Pregnil", "Profazi", "Khoragon". All drugs containing hCG are prescribed by a doctor according to individual indications, unauthorized treatment with them is strictly prohibited, since it can lead to a strong hormonal imbalance in the human body.




As the name suggests, the main active ingredient of the drug is human chorionic gonadotropin. In the body of the expectant mother, it is entrusted with the most important functions - to stimulate the corpus luteum, which is formed after ovulation, to help the production of large amounts of progesterone and estrogen, to preserve the embryo and create the most comfortable conditions for it.

Partially gonadotropic hormone suppresses the aggression of maternal immunity. Without this, the woman's immune defense would simply reject the fetus, which has 50% of the foreign chains inherited from the father in its DNA.


The strong action of the base substance is used for a wide variety of medicinal purposes. The drug in injections is prescribed for women, men and adolescents. However, the drug is most often used in gynecology and obstetrics.

Action

Chorionic gonadotropin is directly involved in the synthesis of sex hormones in both men and women. This substance significantly improves the process of production of substances in the testicles of the stronger sex and in the ovaries - in women. It affects the key "event" of the female cycle - it is this hormonal drug that is used to stimulate ovulation, if for some reason it does not occur in a woman on its own, anovulatory cycles take place.


After ovulation has occurred, the drug helps to maintain the functions of the corpus luteum - a follicle that produces hormones important for the onset of pregnancy - progesterone and estrogens. Under the influence of gonadotropic hormone, the genitals of both men and women develop correctly, and secondary sexual characteristics are formed normally.

Due to its wide spectrum of action, the drug is highly valued by reproductive specialists and obstetricians. It allows you not only to get pregnant, but also to support a "problem" pregnancy, which without hormone therapy is likely to end in miscarriage or premature birth.


Who is the drug prescribed to?

HCG injections are recommended for all women and men who visit a doctor with gutters to reduce sexual function. This includes a weak sex drive, and the inability to get pregnant on their own, and problems with reproductive functions in men.

The drug is indicated for people suffering from underdevelopment of the genitals, insufficient reproductive capabilities, dwarfism, dysfunction of the pituitary gland and hypothalamus, due to which the hormonal background is disturbed. The tool is widely used in adolescence if there is a delay in puberty.


In gynecological practice, the drug is prescribed:

    women with dysmenorrhea (severe pain during menstruation, additional unpleasant symptoms of "critical" days - nausea, vomiting, headaches, dizziness, loss of consciousness);

    women with ovarian dysfunction;

    women with infertility associated with the lack of ovulation in the cycle;



    women who cannot get pregnant due to insufficiency of the corpus luteum;

    for patients to stimulate ovulation before embryo transfer using IVF, as well as after embryo transfer to maintain pregnancy;

    patients who have already had several miscarriages, especially in the early stages (recurrent miscarriage);

    pregnant women with pronounced signs of threatened termination.


Indications for the use of the drug are also hereditary problems with reproductive function in women and men.

To whom is the medicine contraindicated?

In some cases, the use of the drug will have to be abandoned, because it has a fairly large list of contraindications. So, "Chorionic Gonadotropin" cannot be used for:

    hypersensitivity to this hormone, which can become the beginning of a severe allergic reaction;

    with ovarian carcinoma - a cancer of the reproductive gland in women;

    with neoplasms and tumors in the pituitary gland;


    with the so-called hormonal tumors in the body, which are able to respond with rapid growth to the introduction of androgens;

    with insufficient work of the thyroid gland;

    with dysfunction or insufficiency of the adrenal glands;

    with an increased level of the hormone prolactin in the patient's blood;

    with the onset of menopause, menopause;


    with epilepsy;

    with obstruction of the fallopian tubes, with a strong adhesive process in them;

    during breastfeeding;

    with diagnosed thrombophlebitis.


With increased precautions, the drug is prescribed for women with coronary heart disease, high blood pressure, renal failure, both acute and chronic, suffering from bronchial asthma.

Side effects

Like any hormonal drug, Chorionic Gonadotropin is capable of causing an allergic reaction. Usually it is local in nature, redness, slight swelling and mild itching are observed only at the injection site. Much more often the drug causes headaches. Many women complain that they feel "overwhelmed", constantly tired, some even get depressed.

If the drug is used in combination with other agents as part of complex therapy for reproductive techniques, for example, with "Clomiphene", ovarian hyperstimulation syndrome may develop, when cysts form in the ovaries, which are dangerous from the point of view of the possibility of their sudden rupture. In this case, the appearance of fluid in the abdominal cavity and chest cavity is not excluded.


Sometimes women complain of swelling, mood swings, and uncontrollable bouts of aggression. All this is the result of the effect of the hormone on the brain. It is not necessary that every patient will experience these symptoms of side effects from taking the drug, but everyone should know about the possible consequences.



Instructions for use - dosage

The drug is available in the form of a powder, from which a solution for injection can be prepared. The box also contains an isotonic sodium chloride solution for this. Therefore, the preparation of a ready-to-use tool of labor will not be. The drug is administered exclusively intramuscularly.

The dosage depends on what is the purpose of using the drug. Women who are going for IVF or to stimulate ovulation are injected with 5000-10,000 IU of the drug once. If the treatment is carried out with the use of other means, it is important that at least a day has passed from the last intake of menotropins, and at least five days from the last intake of Clomiphene.


If the patient has insufficient functioning of the corpus luteum, then the optimal dosage for her is 1500 IU. The injection is given every two days until the moment when menstruation either begins or the test confirms the long-awaited pregnancy. The first injection is given on the day of ovulation.

The solution for injection is prepared immediately before the procedure; you should not do this in advance. The dosage of the active substance in the packages offered on the pharmacists' shelves is 500 units, 1000 units, 1500 units, 5000 units. The doctor will tell you the most suitable form, since the treatment must necessarily take place under the supervision of an experienced specialist.


Application to stimulate ovulation

Ovulation is the release of a mature and finished egg from a mature follicle. It usually occurs in the middle of the cycle. For various reasons, the egg may be weakened, against the background of a lack of female hormones, it may not make a timely release or not mature. This is why fertility treatments often start with the promotion of healthy and normal ovulation.

Ovulation calculator

Cycle duration

Duration of menstruation

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  • Ovulation
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Indicate the first day of your last period

This method allows you to achieve success in about 70-75% of cases, if everything is done correctly and there are no contraindications for the use of "Chorionic Gonadotropin". An important condition is the integrity of the egg. It must not be damaged. This stimulation is preceded by a thorough examination. As part of the diagnosis, doctors check the state of the hormonal background of a woman who dreams of motherhood, examine the health of her reproductive system, finding out whether the fallopian tubes are passable, whether there are adhesions, as well as ovarian cysts.


If these pathologies are absent, then complex therapy is used. After menstruation, a woman is prescribed "Klostilbegit" and she should take it up to the 9th day of the cycle.

Then an ultrasound scan is performed, which determines the size and number of follicles. As soon as one of them reaches the desired size, you can make the hCG angle. The drug is administered at a follicle size of 17 millimeters (preferably 19-22 mm). For this, the imported drug "Pregnyl" is often used, it has proven itself well.



Thus, "Clostilbegit" helps to prepare the egg for release, and the gonadotropin promotes rupture of the follicle and release of the egg. Dosages and treatment regimen are prescribed for each patient on an individual basis, because each woman has her own reasons for infertility, her own characteristics of the menstrual cycle. The prescribed course can be adjusted if it turns out on intermediate ultrasound that the therapy is ineffective, that symptoms of superovulation have appeared - cysts on the ovaries. The task of the doctor in this situation is to prevent their rupture; for this, hormonal treatment is canceled.


Many women who are going to have an ovulation stimulation procedure wonder how long after an injection ovulation occurs. The answer to this question is given by the manufacturers of the Russian-made drug. The official instructions for the use of the drug indicate that the long-awaited moment after the injection occurs after 32-36 hours. For imported manufacturers, the interval is identical.

It is not at all necessary that the angle be unit. As indicated above, the dosage for one injection is from 5,000 to 10,000 units, but the injections themselves can be up to three. It all depends on how the female body reacts to the hormonal attack, and whether it is possible to achieve the desired state of the follicle for conception. In IVF, ovulation is stimulated with a single dose of 10,000 units. The most effective are injections into the abdomen with a short needle (from an insulin syringe), this intramuscular method of drug administration is most often used.


For more successful planning during the preparation and conduct of ovulation stimulation, a woman is recommended to donate blood for progesterone and estradiol in dynamics, measure basal temperature daily, and also observe the sex life prescribed by the attending doctor.

Post-injection tests

The issue of using various tests after hormonal therapy with hCG drugs deserves special attention. The level of the hormone received by the female body "from the outside", of course, affects the results and analyzes that can be carried out later. Therefore, it is recommended to do an ovulation test no earlier than three days later, and a pregnancy test after an injection will not be informative for at least 12 days. More often than not, the woman will see the second strip, but the result will be false positive.


The concentration of the hormone obtained during the injection leaves the body in about 12 days. Therefore, doctors do not advise starting to buy pharmacy tests earlier than the fifteenth day after ovulation. The best option is a blood test for hCG. If you do it several times, then the dynamics will be noticeable. Positive if pregnancy has occurred, and negative (the level will decrease) if conception did not take place.


Pregnancy maintenance

An insufficient level of intrinsic chorionic gonadotropin is primarily manifested by a high probability of early miscarriage. Lack of this hormone leads to insufficient production of progesterone - the hormone "responsible" for maintaining pregnancy. Therefore, a low level of hCG can lead to intrauterine death of the embryo and a frozen pregnancy.

If a woman has already had pregnancies according to this scenario, she will most likely be offered hormonal therapy with Chorionic Gonadotropin. If a woman suffers from habitual miscarriage, then she is recommended to identify the fact of pregnancy as early as possible using modern diagnostic methods and start treatment with this drug or its analog on time.


It is important that the first injections during early pregnancy are given before obstetric week 8 and completed by week 14. This also applies to cases when a woman first develops symptoms of an early threat of spontaneous abortion.

The dosage, depending on the type of pathology, ranges from 1000 to 3000 units. Injections are given every two days, after 10 weeks - every 3-4 days up to 14 weeks, when the threat is considered a successfully completed stage.

If the problem of miscarriage is malfunction or dysfunction of the corpus luteum, the dosage can be from 1500 to 5000 units for one injection. If recurrent miscarriage is caused by immune or hormonal reasons, then the first dose will be 10,000 units, and the next dose will be 5,000 units. In case of miscarriages of an unclear etiology, the causes of which could not be established, any dosage can be prescribed, except for 10,000, this issue is decided by the attending physician, based on the results of a biochemical blood test.


In the course of a long course of treatment, a woman will have to follow other recommendations, without which hormone therapy may be ineffective. She will have to visit a gynecologist more often, more often to do an ultrasound scan to monitor the condition of the cervix and cervical canal, as well as to monitor the growth and development of the embryo, donate blood several times for hormones and biochemical analysis. In case of a serious threat, a hospital stay is recommended.

If problems with conceiving and carrying a baby are associated with endometriosis, the doctor may prescribe hormonal gonadotropin agonists - releasing hormone. Women should understand that such drugs do not affect the ability to conceive a child, they only help prepare a woman's body for further attempts to conceive a baby, help cope with endometriosis.


special instructions

    It is a mistake to believe that a single injection of hCG during ovulation stimulation will help cure a woman from anovulation. The drug only stimulates the release of a single egg in a specific cycle. The effect of the drug does not apply to other cycles.

    When agreeing to treatment with this hormonal drug, a woman should be aware of such a consequence of gonadotropic therapy as multiple pregnancy. Often, a woman who is stimulated to ovulate with a large dosage of hCG (10,000 units) eventually becomes a happy expectant mother of not one, but two or three babies at once.

    Many women complain that the lower abdomen hurts after the injection. This should not be scary, because the hormonal injection is quite painful, gradually these post-traumatic pains will go away.


    If you take a drug of human chorionic gonadotropin for too long, then the body can develop antibodies that will prevent the production of this useful and necessary substance in certain situations. This will greatly complicate future pregnancies, making conception and bearing a child practically impossible.

    Both the original drug and its foreign analogues are not recommended to be combined with alcohol and narcotic drugs. The question of the compatibility of the hormone with alcohol, which often sounds in many women's forums, generally raises a reasonable answer about the inadmissibility of alcohol during the planning period in general, with an assisted reproductive technique - in particular.


    • An isotonic solution is injected into an ampoule with a powder of the drug and mixed well until uniform distribution without precipitation. Stir in a circular motion and in no case shake the ampoule.

      The ready-made solution is drawn into a syringe, the needle is changed to a regular one, if it is decided to inject into the buttock, or to a small "insulin" one, if it is planned to inject into the abdomen.

      Cotton wool dipped in alcohol or special pharmaceutical alcohol wipes is used to wipe the injection site.

      The drug is administered intramuscularly, not quickly.

      After the injection, an alcohol napkin is applied to the injection site and lightly pressed for 1-2 minutes.


    The method of administration of the drug into the abdomen is most often used to stimulate ovulation. For a systematic intake on a schedule while maintaining pregnancy, it is better to inject chorionic gonadotropin into the gluteus muscle.

    Overdose symptoms

    Hormone overdose can manifest itself with ovarian hyperstimulation. The appearance of a cyst on the gonads can be indicated by a deterioration in the well-being of a woman. There may be a sharp pain in the lower abdomen, nausea, vomiting. The pain occasionally "shoots" into the groin area. In many women with acute hyperstimulation syndrome, there is a feeling of intestinal bloating, distention.

    The appearance of diarrhea is not excluded, but at the same time the amount of urination decreases, the woman begins to edema of the lower extremities and hands, breathing becomes more frequent.

    Storage conditions and dispensing from pharmacies

    The drug belongs to pharmacological group B, it can be bought in pharmacies only with a doctor's prescription. Store boxes with solution and dry powder for dilution at a temperature not exceeding 20 degrees Celsius, so that direct sunlight does not fall on the medicine.

    If a diluted solution remains after the injection, it cannot be used again, it is advisable to prepare a new portion of the solution for a new injection, and the remains do not need to be stored at all, either in the first-aid kit or in the refrigerator.


Women planning to have a baby face many unfamiliar medical terms. Their meaning remains a mystery until you personally encounter them. These include the hCG hormone, which is produced by the female body after fertilization and is responsible for the proper development of the fetus. But sometimes a failure occurs and its artificial introduction is required. This is possible with the help of special injections that contain a substance - chorionic gonadotropin. It is done during pregnancy planning for women who do not ovulate.

Under what circumstances do you need an injection of hCG?

The ability to become pregnant occurs only when the egg is released from the ovary. This happens somewhere in the middle of the menstrual cycle. Sometimes the fertilized egg does not attach to the wall of the uterus. The couple tries for a long time, but nothing happens, since the long-awaited ovulation does not occur. It can be caused by stimulation, but for this it is necessary to find out the causes of the failure and eliminate them.

HCG injection is able to restore ovulation, but the choice of the drug and its dosage are prescribed only by the doctor based on the characteristics of each woman individually. After the introduction of the selected agent, the favorable period should come in a day or one and a half, but this is an approximate time, because sometimes ovulation begins much later.

  • to stimulate the egg and prevent the formation of a cyst, which can occur when the follicle does not burst, but begins to decrease in size;
  • in cases where the placenta does not develop well. An injection of hCG is injected to help her. He contributes to its formation;
  • to maintain the efficiency of the corpus luteum. The body in the initial stage of pregnancy really needs its support, then the placenta can take over this function;
  • at risk of miscarriage. Especially if in previous cases of pregnancy they have already been;
  • in case of artificial insemination.

Important! During stimulation, the success of follicle development must be monitored by ultrasound. With male infertility, injections with hCG are useless.

If, after all the examinations, it turns out that such a procedure cannot be dispensed with, then it is necessary to provide the doctor not only with the results of female tests, but also with her partner. He is required to pass a spermogram in order to be sure of a man's ability to conceive. This can be understood by the quality of his semen. Many representatives of the strong half believe that if they have not had any problems before and their older children confirm this, then they are deeply mistaken. The situation can change during the year and how many children there were before that does not matter.

In what cases should hCG not be done?

Before stimulation, you need to pass tests to check hormones. This is necessary to clarify their exact indicators; it is better to do this several times. After detecting a problem, the doctor will probably prescribe a course of normalizing hormone levels, and if this therapy does not help, then you will need to resort to an injection of hCG.

But there are hormones, in violation of which stimulation cannot be carried out, these are:

  • prolactin;
  • thyroid gland;
  • and almost all men.

They can interfere with the process and it will be ineffective.

It is strictly forbidden to give injections with hCG if the following diseases are observed:

  • tumors of the ovaries and pituitary gland;
  • hypothyroidism - a lack of thyroid hormones;
  • existing blood clots in blood vessels or a predisposition to their appearance;
  • early menopause;
  • sensitivity to the ingredients of the injection.

Important! If obstruction of the tubes is detected, then the stimulation of ovulation can lead to ectopic conception. Therefore, before the procedure, it is imperative to undergo laparoscopy and metrosalpingography.

Indications of ultrasound monitoring for hCG

On average, a woman's monthly cycle lasts 28 days, so the first ultrasound can be done 10 days after the last menstruation. The procedure should be carried out every three days until the ovulation period is established or the next "women's days" begin.

Observation results can be:

  • lack of ovulation, because the ovaries do not work and the follicles do not mature;
  • the main follicle matures, but does not grow to the required size and ovulation does not occur;
  • the follicular sac develops normally but then does not rupture.

Stimulation is not required only in the event of ovulation and the formation of the corpus luteum in the follicle. And if she does not open up in time, you can help her do it with a timely injection of hCG, after which a yellow body will appear in place of the follicles.

Stimulation procedure

The doctor usually prescribes an injection of chorionic gonadotropin on the second day of the cycle. It must be done daily, and after ten days the stimulation stops. The whole process takes place under the supervision of a doctor, he also prescribes how many days to give injections and what should be the doses of the injected drug.

Important! There is no need to focus on average indicators or stimulation from friends. For each patient, everything goes individually, this is due to the structural features of the ovaries and uterus of a single woman.

Treatment is accompanied by constant monitoring for ultrasound every three days. The first is carried out after stimulation on the fifth day. And when the follicles grow to the desired size (about 20-25 mm), then a final examination is carried out, checking their disclosure. For its successful completion, an injection of hCG is administered, during this period it provokes the start of ovulation.

If all circumstances are favorable, then the injection will take effect after 36 hours and ovulation will begin. After this is confirmed on an ultrasound scan, hormonal injections with morning and progesterone will be prescribed, which are needed to support the activity of the ovaries.

How many and when sexual intercourse should be carried out during stimulation is prescribed by a doctor, this is influenced by the male factor. After the injection, you can try the next day. They should be repeated until the corpus luteum appears, that is, until the period when ovulation occurs.

The growth of hCG begins to be observed already on the third day, and every 3 days it doubles. Under the influence of the injected injection, the body begins to produce at a doubled rate: progesterone and estrogen, and they contribute to conception.

An injection of hCG is often used in gynecology to stimulate ovulation, it effectively helps with infertility, and promotes the early conception of a long-awaited baby. After its introduction, there is no need to wait for the results for a long time, moreover, in most cases they are positive.

On the proposed video, the specialist will clearly explain the significance and effect of the hCG injection.