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Utrozhestan and dyufaston are hormonal preparations for maintaining pregnancy. What is better Dyufaston or Utrozhestan


Hormonal drugs to maintain pregnancy

Doctors know that almost no pregnancy is complete without prescribing at least some kind of pill. And even if we are talking about "harmless" vitamins, pregnant women have natural questions: why is it necessary to take the medicine and how safe is it for the unborn baby? In this section, we will tell you about the medications that are usually prescribed to expectant mothers.

The drugs UROZHESTAN and DUFASTON are usually prescribed to expectant mothers when such a common problem as the threat of termination of pregnancy occurs. These drugs contain the hormone progesterone, under the influence of which important biological processes take place in the woman's body, contributing to the successful bearing of the fetus.

The effect of progesterone on a woman's body is aimed, first of all, at providing favorable conditions for fertilization, attachment to the uterine wall and development of the ovum. The lack of production of this hormone often becomes the cause of such an unfavorable episode of pregnancy as a miscarriage of the first trimester, because it was during this period that the ovum had not yet firmly attached to the uterus and the mother's hormonal background had not been fully and steadily formed.

The hormone progesterone refers to gestagens - female sex hormones produced in the ovaries. Even before fertilization, he prepares the uterus for the adoption of the embryo, stimulates the development of the mammary glands. With a lack of progesterone, the mother's body gives an incorrect signal to the immune system, as a result of which the fetus is perceived by the body as a foreign agent, and this leads to the detachment of the trophoblast - the "leaf" feeding the fetus, from which the placenta should form in the future. As a result, a first trimester miscarriage may occur.

Progesterone began to be used to treat the threat of termination of pregnancy back in the 60s - 70s of the last century, but at the same time its side effects on the child and on the mother were fully manifested, in particular, it was not possible to avoid fetal malformations. Only with the development of high technologies and the possibilities of using molecular methods of synthesis was it possible to obtain drugs that can qualitatively and safely deal with this unfavorable moment of pregnancy. These drugs include DYUFASTON and UTROZHESTAN.
DUFASTON

DUFASTON is a potent progestogen hormone. which, in terms of its molecular structure and pharmacological action, is close to endogenous (i.e., produced by the body) progesterone and, as a result, has a high affinity for progesterone receptors (structures that perceive the action of this hormone), i.e. fits them perfectly like a key to a lock.

The "synthetic" change in the configuration of the molecule leads to the fact that DUFASTON is easily absorbed when taken orally. Unlike many hormones-gestagens, DUFASTON is not a derivative of the male hormone testosterone - its structure differs from the structure of most synthetic gestagens, as a result of which the drug is devoid of their characteristic side effects. Unlike other synthetic gestagens, DUFASTON:
does not cause the appearance of "female" signs in a male fetus and does not have side effects on liver function and blood clotting;
does not cause such manifestations as acne, coarsening of the voice, hirsutism (increased hair growth) and masculinization of the genitals (enlarged clitoris) in a female fetus;
does not cause changes in the lipid spectrum of blood and glucose concentration;
does not negatively affect other organs of internal secretion.

The high safety of DUFASTON, confirmed by many years of experience in its use (there was not a single case of detection of intrauterine fetal malformation), allows you to confidently use the drug as a hormonal support. In addition, in comparison with UTROZHESTAN, dydrogesterone does not have a sedative (calming) effect. Sometimes this factor contributes to the fact that this particular drug is chosen for treatment.

Thanks to its unique correspondence to natural progesterone, DUFASTON recreates the natural mechanisms of the normal course of pregnancy. The results of many studies on this drug are inspiring: the use of DU-FASTON halves the incidence of placental insufficiency and premature birth. And children less often have a lack of mass at birth, receive a higher score on the Apgar scale (according to this scale, all newborns are assessed, while paying attention to breathing, heartbeat, reflexes, skin, muscle tone). In newborns, hypoxic (i.e., oxygen deprivation) brain damage is less common. The birth rate of healthy children increases by one third.

Of the side effects, in rare cases, uterine bleeding is possible (in this case, you must immediately consult a doctor). No other side effects have been identified with this drug.

The only significant contraindication for taking DUFASTON is hypersensitivity to the components of the drug, that is, individual intolerance.

DUFASTON (dydrogesterone) is a synthetic analogue of natural progesterone, UTROZHESTAN is a natural progesterone. This is their main difference, which leads to some differences in the effects and in the use of these drugs.

Dydrogesterone is excreted in breast milk, therefore, if it is necessary to use the drug during lactation, the doctor raises the question of stopping breastfeeding.

DUFASTON is especially often used when using IVF technology - in vitro fertilization. Numerous observations show that the use of a synthetic drug in IVF is more effective than a natural natural analogue, although large international studies on this matter have not been published. Long-term use of this drug in a large dose is possible due to the advantages of DUFASTON - high stable availability to tissues and the absence of side effects.
UTROZHESTAN

UTROZHESTAN is the only progesterone in the world produced from plant materials. This preparation is natural micronized, i.e. produced in a special form, progesterone (the hormone molecules are surrounded by peanut butter). It is produced in the form of capsules for oral (inside) and intravaginal (in suppositories) use.

This drug has a complete resemblance to the progesterone molecule, and it is this property that provides a number of unique effects that distinguish it favorably from other drugs in this group. UTROZHESTAN fully possesses the properties of endogenous (produced in the body) progesterone. It promotes pregnancy, prepares the endometrium for egg implantation. UTROZHESTAN (like DUFASTON) does not change body weight and does not contribute to fluid retention in the body, does not affect lipid and carbohydrate metabolism and does not increase blood pressure.

The unique structure of the UTROZHESTAN molecule allows it to influence the exchange of male hormones androgens (and they are also present in women during pregnancy). which not only has a positive effect on the course of pregnancy, but also improves the condition of the skin.

UTROZHESTAN also has a positive effect with an increased amount of male sex hormones in a woman (hyperandrogenism) due to the fact that this drug interacts in the body with the same receptors as androgens, i.e. competes with them.

Another unique mechanism of preserving and maintaining pregnancy for MOROZHESTAN is its ability to suppress the effects of oxytocin (this hormone is also produced by the ovaries, and it is this hormone that stimulates uterine contraction and leads to miscarriage). This effect of UTROZHESTAN is especially pronounced when taken orally.

The usual dose of UTROZHESTAN is 200-300 mg per day, and either of the two routes of administration of the drug can be used - intravaginal or oral. When eliminating the threat of termination of pregnancy, the combination of intravaginal administration of UTROZHESTAN with oral administration is more preferable and effective. It is important to note that the initial dose of UTROZHESTAN with the threat of termination of pregnancy is 400-600 mg at a time, followed by a maintenance dose of 400-600 mg per day. If this therapy is ineffective, the dose of UTROZHESTAN can be increased to 800-1000 mg per day. But the appointment of treatment, like changing the dose, should be carried out only by a doctor, since this is a hormonal drug, and its overdose or lack in the body can tragically end for pregnancy. Cancellation of UTROZHESTAN or a change in its dose is carried out under the control of various indicators of pregnancy, including the concentration of progesterone in the blood: it changes smoothly during normal pregnancy - and the cancellation should also occur without "bursts".

Let's say a few words about the side effects that can occur when taking this drug. Like "own" progesterone, UTROZHESTAN slightly increases body temperature and has a calming and hypnotic effect, more pronounced when taken orally. When taking the drug inside, drowsiness and dizziness may also occur.

In case of serious liver diseases, the intake of UTROZHEST inside is contraindicated - it is recommended to switch to intravaginal use, since the drug is actively metabolized (processed) by the liver.

In conclusion, let me remind dear mothers that if a doctor prescribes any of the considered drugs for a pregnant woman, then this means a full and serious treatment, since it is associated with the intake of hormones, the minimum changes in the concentration of which in the blood (including without the knowledge of the doctor) in that or the other side can be canceled out by both the efforts of the doctor and your pregnancy. Therefore, while taking these medications, constantly keep your finger on the pulse - visit your doctor regularly and strictly follow his advice.

Not all women manage to successfully get pregnant and bear a child. In connection with the restructuring of the body of the expectant mother, dangers await her from all sides. Miscarriages are very common complications. The most common cause of spontaneous abortion is low progesterone levels. When a threat of bearing a child is detected during pregnancy, hormonal drugs dyufaston or urozhestan are prescribed, which replenish the missing hormone in the female body.

Progesterone

To fully understand the mechanism of action of both drugs, the concept of progesterone should be considered in more detail. This hormone is a steroid produced in the female body. It is most actively produced by the placenta during pregnancy.

Progesterone is the main hormone of the corpus luteum of the ovaries. The substance is actively produced in the second half of the cycle. This is necessary for the normal anchorage of the fertilized egg on the endometrium. In the absence of fertilization, the amount of progesterone begins to decline.

In the case of fertilization, the hormone is produced by the corpus luteum intensively for some time, until the placenta begins to synthesize it on its own. A low amount of progesterone is a common cause of infertility in women. Therefore, first of all, women who want to get pregnant should monitor the level of this hormone.

Features of medicines

Both hormonal drugs have an identical composition, but their main difference is as follows:

  • Utrozhestan is made on the basis of a natural substance.
  • Duphaston is a synthetic agent.

The drugs have a similar effect on the woman's body, and their main task is to maintain pregnancy and treat infertility or other diseases caused by hormonal imbalance. But in order to understand that it is better than dyufaston or morning, you need to consider each drug separately.

Hormonal drugs are prescribed after an examination and testing for the level of progesterone in the blood. After all, hormonal imbalances are not always the cause of infertility or miscarriages. Independent use of these medicines is strictly prohibited.

Utrozhestan

The drug is made exclusively from plant materials, therefore the progesterone molecules in this drug are absolutely identical to the natural substance produced in the female body. Utrozhestan is produced in two forms:

  • capsules intended for oral administration,
  • suppositories used for intravaginal use.

The effectiveness of pregnancy has been proven with a high level of male sex hormones and hormonal infertility. The drug promotes fertilization, so it can be used to plan pregnancy. Also, the drug is prescribed in other cases, namely:

  • danger of spontaneous abortion,
  • disruptions in the menstrual cycle,
  • mild mastopathy,
  • chronic miscarriage,
  • high levels of male hormones in the body,
  • IVF procedure,
  • endometriosis,
  • uterine fibroids and other gynecological pathologies.

Utrozhestan has quite a few contraindications. It is they who do not allow us to assert that this drug is better than its synthetic counterpart.

The medication is not used for the following factors:

  • internal bleeding
  • incomplete abortion,
  • cerebral hemorrhage,
  • increased content of porphins in the blood,
  • intolerance to one or more of the ingredients of the medicine.

With extreme caution, the drug is prescribed in the following cases:

  • with hepatic and renal failure,
  • with cardiovascular diseases,
  • with varicose veins.

In addition, improper use can cause various side effects - headaches, bleeding in the middle of the cycle, disruption of bowel function.

Duphaston was developed by the pharmaceutical industry before morning. Therefore, the experience of using the drug is longer. The altered "synthetic" configuration of the hormone leads to the fact that the drug is rapidly absorbed when taken internally. In addition to the fact that the drug is widely used to exclude spontaneous abortion, it is used:

  • in preparation for in vitro fertilization,
  • for replacement therapy after surgical castration and during menopause,
  • with various pathologies of the menstrual cycle,
  • in the presence of endometriosis,
  • with uterine bleeding in case of disturbances in the functioning of the organs of the reproductive system.

Recent studies have shown that dyufastone halves the likelihood of preterm birth in women at risk. In this case, the drug is allowed to be taken constantly during pregnancy, since it does not have a negative effect on the fetus. But due to the fact that the drug penetrates into breast milk, it must be canceled after childbirth.

Duphaston has practically no contraindications. The drug is not prescribed for serious liver pathologies, intolerance to any component, as well as for rare diseases such as Dabin-Johnson and Rotor syndromes. Uncontrolled drug intake provokes the development of side effects in the form of headaches, allergic reactions

Which drug to give preference

The question of which drug is better cannot be answered unequivocally. When appointing both morning and dyufaston, the doctor must take into account the individual characteristics of the patient and the purpose of using the medicine. Both drugs do not affect body weight, since they do not lead to fluid retention in the body. This is a very important factor for a woman carrying a baby. Medicines do not affect lipid and carbohydrate metabolism, that is, they do not provoke disruptions in metabolic processes. It is also very important that the drugs do not raise blood pressure.

But at the same time, most doctors agree that duphaston is safer during pregnancy, since it has fewer side effects. Unlike a crop, it does not summon:

  • drowsiness,
  • lethargy
  • rapid fatigue,
  • a tendency to depression.

Duphaston has no toxic effect on the liver, highly effective in IVF. The drug is considered safe, which has been confirmed by long-term studies.

Utrozhestan is a new hormonal drug and its effect on the fetus has not been sufficiently studied, therefore, in some European countries, it is not prescribed to women when carrying a child. Although a significant advantage of this drug is its release in the form of intravaginal suppositories, which is very important for maintaining pregnancy in the first trimester against the background of a possible severe toxicosis.

One of the advantages of pregnancy is that it has a calming effect, which allows you to get rid of various subconscious fears during pregnancy. Drowsiness and apathy, which can occur as a side effect after taking morning sickness, disappears within a couple of hours. But it is during this period that you should be especially careful about your actions, for example, it is better not to drive a car.

In addition, this drug gives good results when used for the treatment of hyperandrogenism.

In the later stages, when the fetal placenta is fully formed and begins to produce the required amount of progesterone itself, as a rule, previously prescribed hormonal drugs are canceled in order to prevent miscarriage. But if the threat of spontaneous abortion remains, you can continue to drink duphaston. Due to the increased risk of liver dysfunctions, uterus is not prescribed during this period.

Hormonal drugs can be used to plan the birth of a child. They contribute to the fact that the likelihood of fertilization increases significantly during the period of taking medications. But at the same time, dyufaston, unlike morning, can be taken for a longer time. In addition, recent studies have shown a positive immune interaction between the expectant mother and the embryo when taking duphaston.

During the period of bearing a child or to stabilize the hormonal background, both hormonal preparations are prescribed by the doctor according to a special scheme and in an individual dosage. At the same time, independently without prior agreement with the doctor, it is impossible to draw conclusions that it is necessary to replace the prescribed medicine with an analogue. This can provoke a miscarriage or lead to hormonal disruption, which is very dangerous for the health of a woman in general. Refusal from the drug and replacing it with another is carried out gradually according to the scheme under the supervision of a doctor.

Recently, many families have problems with the appearance of long-awaited offspring. There are many reasons for infertility, but hormonal imbalance is one of the most common. In cases where the desired two strips do not appear on the test, the doctor prescribes Utrozhestan and Duphaston when planning a pregnancy. These are preparations of the female sex hormone progesterone, without the normal concentration of which conception is impossible.

There are two phases in the menstrual cycle:

  • follicular - from the beginning of the cycle (considered from the first day of bleeding) to the moment of ovulation (14 days on average). During it, an egg matures in the ovary inside the follicle - a small sac of fluid;
  • luteal - occurs after ovulation and lasts until the onset of bleeding. The follicle remaining on the surface of the ovary after the release of the egg from it is transformed into the corpus luteum of pregnancy - a small island of hormone-producing tissue. It releases progesterone, which prepares the uterus for pregnancy. If conception has not occurred, the concentration of the hormone drops sharply and menstruation begins.

The main functions of progesterone

It belongs to the group of steroid hormones, it acts through specific receptors on the uterus and other organs. The effect of progesterone on a woman's body:

  • prepares the inner lining of the uterus (endometrium) for the possible introduction of a fertilized egg;
  • if pregnancy has not occurred, initiates menstrual bleeding;
  • relaxes the muscle layer of the uterus for better stretching during fetal growth;
  • reduces the motor activity of the fallopian tubes - this is how its contraceptive effect is manifested;
  • increases the viscosity of the mucus of the cervical canal of the uterus. This protects the growing baby from infections;
  • lowers the activity of the immune system to maintain pregnancy. The embryo consists of proteins that are foreign to the mother's body, so immune cells can provoke a miscarriage.

After ovulation (the release of a mature egg from the ovary), there is a sharp increase in the concentration of progesterone. It acts on the endometrium and prepares it for pregnancy. If the release of the hormone occurs later or too little, the fertilized egg cannot attach to the endometrium and dies. This is how one of the mechanisms of female infertility is formed.

There are many medications that contain progesterone. Most often in gynecological and obstetric practice, Utrozhestan and Duphaston are used.

Utrozhestan or Duphaston - which is better when planning a pregnancy?

Many women ask themselves: does Duphaston and Utrozhestan help to get pregnant? Let's take a closer look at each of the drugs.

Utrozhestan

A natural progesterone preparation for oral administration and vaginal administration. Available in soft capsules of 100 and 200 mg. It is part of complex therapy in the treatment of infertility, cycle disorders and preparation for IVF (in vitro fertilization).

Can be used when planning a pregnancy. In this case, it is prescribed at a dosage of 200 mg per day, divided into 2 doses (morning and evening). The capsules are not chewed and washed down with water. Utrozhestan should be taken strictly after ovulation, the easiest way to track which is to use a special test. On average, women start taking Utrozhestan when planning pregnancy from the 17th day of the cycle.

Cancellation of Utrozhestan when planning pregnancy can be carried out if it has not occurred in the current cycle, that is, after the start of menstruation. Otherwise, there is a threat of miscarriage due to a sharp drop in the concentration of progesterone. If conception does not occur, the drug is repeated in the same way in the next cycle and so on until the desired pregnancy occurs.

For more information on how to take Utrozhestan when planning a pregnancy, contact your doctor. He will prescribe an examination, check the content of hormones in the blood and determine the required dose of the drug.

Gynecologists are preferable to prescribe Utrozhestan to maintain pregnancy, for which it is taken from the first days of the delay. Such a measure is required in the case of frequent miscarriages, threatening abortion, hyperandrogenism. The latter condition develops as a result of an increased content of male sex steroids in a woman. It is manifested by increased body hair, a low timbre of voice, a boyish type of figure - the shoulders are wider than the pelvis.

When planning pregnancy, Utrozhestan is less effective than similar drugs. Among the side effects, women note drowsiness, dizziness and a slight increase in body weight.

The average price of Utrozhestan is 400-450 rubles per package.

Duphaston

The synthetic analogue of progesterone is dydrogesterone. Available in 10 mg tablets for oral administration. Women are often interested in the question: what is Dufaston prescribed for?

The drug is widely used in gynecology for replacement therapy for progesterone deficiency, uterine bleeding, and cycle disorders. Due to its structure, it does not have the side effects inherent in other drugs of the progestogen group.

Duphaston for conception begins to be taken in the luteal phase of the cycle, from 16 to 25 days. The course of treatment lasts six months or more, in case of pregnancy, the reception is continued up to 12-16 weeks inclusive. It is necessary to cancel the drug gradually, a quarter of a tablet a day. A sharp decrease in the concentration of progesterone will lead to the threat of miscarriage.

It is advisable to determine the hCG of the blood every month of taking Duphaston by the 25th day of the cycle, so as not to miss the onset of pregnancy. Tests for such a short period of time cannot always determine its increase.

You can get more accurate information on how to drink Duphaston to get pregnant from your doctor. He will individually select the dose of the drug, taking into account the initial level of hormones and concomitant pathology. Doctors note the high efficiency of Duphaston in terms of pregnancy, but its use while carrying a baby is controversial. The synthetic nature of the hormone and its safety for the developing fetus are alarming.

How much does Dufaston cost? The average price of Duphaston is 470-550 rubles per package.

Despite the availability of drugs and a large number of treatment regimens published on the Internet, they should not be taken without a doctor's prescription. Uncontrolled intake will be useless at best, and create additional health problems at worst.

Dyufaston or morning - what to choose

Duphaston and urozhestan belong to the group of gestagens or progestins, that is, drugs that have progesterone activity. The chemical formula of urozhestan is similar to the formula of natural progesterone, and there are changes in the dyufastone formula.

What are gestagens or progestins and how they work

The group of gestagens or progestins includes progesterone and its natural and synthetic analogues. Progesterone is a hormone that begins to be produced in the second half of the menstrual cycle after ovulation - the release of an egg from a ruptured follicle (the bubble in which it matured). The ruptured follicle begins to produce progesterone and is called the corpus luteum of the menstrual cycle. If pregnancy occurs, the corpus luteum expands and begins to produce much more progesterone, turning into the corpus luteum of pregnancy.

Ovulation occurs under the action of pituitary gonadrtropic hormones (GTH) - follicle stimulating hormone (FSH) and luteinizing hormone (LH). FSH promotes the maturation of the egg in the first half of the cycle, and when it matures, information about this enters the cerebral cortex and the hormonal background changes. Ovulation always occurs with a sharp jump in the content of LH in the body.

There is an inverse relationship between the ovarian hormones (estrogens and progesterone) and the pituitary hormones: the fewer ovarian hormones, the more HTG is released to stimulate their synthesis. But if there are a lot of ovarian hormones, this inhibits the release of TSH.

Therefore, if progesterone or any other gestagens are secreted in excess, they inhibit the release of LH, and therefore ovulation.

In addition, under the influence of gestagens, the proliferation phase (increase in tissue volume) of the endometrium (the inner lining of the uterine cavity), characteristic of the first half of the menstrual cycle, enters the secretion phase - the tissue begins to secrete a secret that prepares the endometrium for the introduction of a fertilized egg. This ability of gestagens is widely used to treat diseases associated with excessive proliferation of the endometrium against the background of an increased content of estrogen and a lack of progesterone. Such diseases include hyperplasia (overgrowth) of the endometrium and endometriosis. It is also prescribed in case of insufficiency of the luteal phase, when the corpus luteum produces little progesterone.

In the first half of pregnancy, gestagens are prescribed when there is a threat of miscarriage - they suppress the contractions of the muscles of the uterus.

Features of dyufaston

Duphaston is a synthetic progestogen, its chemical formula does not fully correspond to the progesterone formula, but manufacturers (pharmaceutical company Abbott, USA) consider this a plus of the drug. In addition, the instructions attached to the drug indicate that it does not inhibit ovulation, which allows it to be used without calculating the day of ovulation, starting from the 14th and 25th day of the menstrual cycle in case of luteal phase insufficiency. It is believed that such an admission schedule will not prevent a woman from getting pregnant.

Another feature of duphaston is that due to the changed chemical formula, it has very few contraindications and side effects. So, a contraindication for taking it is only an individual intolerance to the components of the drug and the appearance of itching (this may be a sign of liver dysfunction) during a previous pregnancy.

From the side effects of the drug, headaches, breakthrough uterine bleeding, increased sensitivity of the mammary glands, minor violations of liver function are noted (while, oddly enough, Liver diseases: when the natural filter fails are not a contraindication for the appointment of dyufaston) and allergic reactions. Dyufaston does not increase blood clotting with thrombosis and increase body weight characteristic of other gestagens.

Clinical practice shows that duphaston is indeed a high-quality progestogen that rarely gives side effects. But many gynecologists treat infertility - modern methods nevertheless, they try to track the moment of ovulation and only after that prescribe dyufaston.

Features of the morning

Utrozhestan is a natural micronized gestagen and is available in 200 and 100 mg capsules by the French pharmaceutical company Bezen Helska. The micronized form of urozhestan, when taken orally, is rapidly absorbed in the gastrointestinal tract and provides a constant concentration of gestagen in the blood without sharp fluctuations. In addition, the capsules can be administered in [email protected]# $% &, which is very convenient during pregnancy if a woman has signs of early toxicosis, accompanied by nausea and vomiting.

Utrozhestan has more contraindications and side effects, as well as progesterone, which is administered intramuscularly. It suppresses ovulation, promotes weight gain, can cause thrombosis, and adversely affect liver function. Nevertheless, clinical practice has established that urozhestan is well tolerated by women and rarely produces side effects.

Therefore, which drug to choose, Duphaston: helper for the desperate or morning, it is better to entrust the obstetrician-gynecologist

To eliminate the threat of spontaneous abortion, most often doctors choose between Dufaston and Utrozhestan. Both drugs contain the same substance - progesterone, which ensures the safe bearing of the fetus and childbirth without complications. Also, these medicines are used in the treatment of gynecological diseases. Despite approximately the same effect, medicines have several differences in their effect on the body.

Duphaston and Utrozhestan: comparative characteristics of drugs

Dyufaston and Utrozhestan have a similar composition, but differ in the structure of progesterone. The first drug contains synthetic components, the second contains natural ones. When choosing a medication, in addition to the origin of the hormone, the form of release of the medication, contraindications and the likelihood of side effects are taken into account.

Description of medicines

Duphaston contains a synthetic analogue of progesterone - dydrogesterone. Unlike other artificial female sex hormones, it does not have androgenic activity, is easily absorbed by the body and practically does not cause complications. It is produced in the form of tablets, each of which contains 10 mg of an artificial hormone.

Comparison shows that Utrozhestan, made from natural raw materials, is stronger in therapeutic effect. The drug reduces the contractility of the uterus and inhibits the proliferation of the mucous membrane (endometrium). It is produced in capsules and suppositories for intravaginal use, which contain 100 and 200 mg of the active ingredient.

Indications and contraindications

Duphaston is most often used in the treatment of gynecological pathologies, in particular dysmenorrhea and endometriosis. It is prescribed for disruptions in the menstrual cycle, symptoms of premenstrual syndrome in women, hormone replacement therapy (HRT). This drug is indispensable for dysfunctional uterine bleeding. The indication for the use of the drug is also infertility and the threat of miscarriage associated with a deficiency of progesterone in pregnant women.

Utrozhestan has similar indications for admission. Due to its natural origin, the drug is often used during pregnancy planning, in IVF and for the treatment of infertility caused by an excess of male hormones in the body. The medication is effective against pathologies such as uterine fibroids and endometriosis.

Duphaston is easily tolerated by patients and has practically no contraindications. It is forbidden to take this medication with individual intolerance to its components and liver pathologies. Despite the fact that the medication does not have a harmful effect on the fetus and can be used during pregnancy, it is recommended to stop taking the drug while breastfeeding.

Utrozhestan has many more contraindications, which is explained by its natural origin.

It is unacceptable to use the drug for the following diseases and conditions:

  • liver and kidney disease;
  • vaginal bleeding of unknown etiology;
  • cerebral hemorrhage;
  • the presence of neoplasms in the genital system and mammary glands.

Scheme of application and dosage

The regimen of the drug is determined by the doctor individually. In addition to contraindications to the drug, the age of the woman and the approximate duration of treatment are taken into account. The average daily dose of Utrozhestan is 200 mg, but may increase depending on the severity of the pathology.

The regimen for taking the drug, depending on the clinical case:

  • planning pregnancy - once a day;
  • IVF - 600 mg (suppositories) 3 times a day;
  • the threat of miscarriage - up to 400 mg daily, divided into 3-4 doses;
  • MMT with menopause - 1 time per day for 25 days.

The daily dose of Duphaston is 10 mg. Depending on the pathology, the following treatment regimens are used:

  • threat of miscarriage - 40 mg once, then 10 mg every 6 hours until the condition of the pregnant woman stabilizes;
  • MMT with menopause - once a day;
  • uterine bleeding - 20 mg 2 times a day;
  • dysmenorrhea, menstrual irregularities - similar to the above scheme from 5 to 25 days of the cycle.

The drug should be taken before or after a meal (after 30 minutes), and in the evening - before bedtime, washed down with water (for more details, see the article :). The treatment continues until a stable therapeutic effect is achieved. As a rule, therapy with Utrozhestan continues during the first trimester of pregnancy (for more details in the article:). If after 3 months of treatment the threat persists, it is recommended to switch to another drug.

In order to avoid remission of the pathology after achieving a therapeutic effect, it is necessary to gradually reduce the dose of the medication. It is recommended to reduce the dosage by 1/4 and carefully monitor the woman's condition. If within a week the pregnant woman is feeling well and there is no risk of miscarriage, the dose is reduced every 7 days, gradually completing the medication.

Side effects

Reception of Duphaston is practically not accompanied by side effects. The drug does not affect the work of the central nervous system, therefore, after taking it, you can safely sit behind the wheel and not interrupt activities that require concentration. In rare cases, there is painful swelling of the mammary glands and uterine bleeding. In the latter case, the doctor increases the dosage of the drug.

Reception of Utrozhestan is accompanied by a number of side effects:

  • hives;
  • headache, drowsiness or, conversely, insomnia, increased fatigue;
  • violation of the menstrual cycle (reduction or appearance of acyclic bleeding), swelling of the mammary glands;
  • bloating, constipation, or diarrhea;
  • joint pain;
  • weight gain.

The listed side effects are eliminated by intravaginal use of the drug or by switching to safe Dufaston. Complications from treatment with suppositories occur in exceptional cases and are most often associated with intolerance to soy lecithin, which is part of the drug. Side effects appear in the form of local reactions:

  • burning;
  • hyperemia;
  • urticaria in the genital area;
  • oily vaginal discharge.

Which drug is more effective?

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Dyufaston and Utrozhestan are equally effective. When choosing a drug, they are guided not by the speed of the therapeutic effect, but by the possible side effects. The difference is that the first medication is easily tolerated and can be used in the last stages of pregnancy. The second drug is preferable to use in the treatment of gynecological diseases.

When planning a pregnancy

When choosing what to take, Duphaston or Utrozhestan, take into account the severity of the pathology that prevents the embryo from taking root. Utrozhestan, which contains natural progesterone, is used for long-term fertility treatments. The medication can be used intravaginally, which ensures rapid assimilation of the hormone, therefore it is prescribed in cases requiring an immediate result, in particular with IVF.

With the threat of miscarriage

Both drugs are equally effective in normalizing the tone of the uterus, preventing miscarriage. In the early stages, Utrozhestan is often prescribed. This allows the embryo to enter the uterus better.

If the risk of spontaneous termination of pregnancy persists in the following months, in order to avoid harmful effects on the fetus, it is better to switch to Duphaston.

Gynecological pathologies

For the treatment of gynecological pathologies, Dufaston is most often used. The drug is especially effective against endometriosis - the proliferation of the endometrium due to progesterone deficiency. The medication is used in conjunction with minimally invasive treatment methods. This prevents the appearance of new foci of inflammation.

Duphaston is prescribed for painful menstruation. Dysmenorrhea is associated with a lack of progesterone and an increase in estrogen production. This hormonal imbalance provokes myometrial hypoxia and intense contractions of the uterus. The drug not only relieves pain, but also eliminates the consequences of dysmenorrhea, such as swelling and feeling unwell.

Can Duphaston and Utrozhestan be used at the same time?

The combined use of Duphaston and Utrozhestan is also possible and is not accompanied by side effects. The appointment of two drugs at the same time is necessary to improve the effectiveness of treatment when a woman is diagnosed with a significant lack of progesterone. The decision on the need to combine medications is made by the doctor after an additional examination.