Suppositories with papaverine indications during pregnancy. Papaverine suppositories: instructions for use. Therapeutic effects of papaverine

21.04.2019

During the period of bearing a baby, the use of any medications can be carried out only as directed by a doctor. Papaverine during pregnancy refers to such a medication. This medicine assigned according to strict indications, has a list of contraindications and a number side effects... The possibility of using it and suitable scheme treatment is determined by a specialist.

Papaverine for pregnant women: benefit or harm?

Papaverine hydrochloride, which is the active substance of the drug, has an antispasmodic effect. This action is based on relaxation of the smooth muscles of blood vessels and organs. Papaverine is widely used in the treatment of some pathological conditions while carrying a child, since it does not have negative effects on the development of the child.

The use of this medication can reduce the tone of the uterus and improve blood circulation in the uteroplacental system.

Moreover, on later dates during gestation, this antispasmodic is prescribed in the form for rectal administration in order to prepare the cervix for disclosure, and immediately during delivery, papaverine reduces the severity pain in the process of contractions.

Based on the above facts, papaverine during pregnancy is undoubtedly a “useful” drug, however, it should in no case be used without prescription qualified specialist... Ignorance of dosages, as well as the mistaken use of this medication, can lead to undesirable consequences up to the need for hospitalization in order to relieve adverse symptoms and medical supervision.

If you are planning to become pregnant or are already carrying a baby, be sure to heed these recommendations.

One suppository for rectal use contains 20 milligrams (ml) of papaverine hydrochloride. As auxiliary substances, type A solid fat or witepsol is used in an amount sufficient for the preparation of a suppository weighing 1.19-1.31 g.

The drug is produced in a cardboard box, which contains two cell packs, each of which contains five suppositories.

Why is papaverine hydrochloride prescribed at different stages of pregnancy?

Papaverine suppositories when carrying a child are prescribed if there are such indications:

Hypertonicity of the uterus and the threat of miscarriage as its consequence. It is the most common reason why papaverine is prescribed for expectant mothers. In acute conditions, in order to maintain pregnancy, the administration of injectable forms of the drug is required.
Arterial hypertension as an independent pathology or as a manifestation of preeclampsia. Papaverine helps reduce blood pressure without negative influence on the fetus.
Colic: intestinal, renal, hepatic. The action of the drug is aimed at relaxing spasmodic structures, thereby eliminating pain syndrome and the functionality of the affected organ is restored.
Bronchospasm. Papaverine helps to relax the bronchi, restore breathing and improve well-being.

The doctor prescribes the drug according to the scheme, depending on the pathology to be corrected and the trimester.

First trimester

Suppositories with papaverine during pregnancy on early dates used in case of increased uterine tone. You should not start using the drug without a medical prescription, so as not to provoke side effects.

In acute clinical situations, when there is a threat of miscarriage, injectable forms of papaverine are used. In other cases, if necessary, suppositories with papaverine are prescribed for early pregnancy. The form of the drug for rectal administration is characterized by high bioavailability and prolonged action.

Second trimester

The papaverine drug in the form for rectal administration in the second trimester is prescribed for abdominal pain, an increase in blood pressure and in the presence of other indications that have already been listed above. At this time, not only papaverine is used, suppositories for pregnant women are combined with other drugs, depending on the clinical situation.

Third trimester

In the later stages of bearing a child, it is rational to use papaverine in case of excessive tone of the walls of the uterus. Also, closer to the preliminary date of birth, a medication is prescribed for the purpose of preparation cervical canal to disclosure. At the beginning generic activity the drug helps to reduce the intensity of pain during labor.

Thus, papaverine hydrochloride in the form rectal suppositories is an effective antispasmodic drug that can be used to relieve various pathological conditions during the period of bearing a child.

The medicine is safe for the fetus, but it can provoke some side effects in the mother's body, so it should be used with caution.

Contraindications and side effects

The list of contraindications to the use of the form of the drug for rectal administration includes:

hypersensitivity to components medicinal product;
high intraocular pressure;
impaired functionality of the kidneys and liver;
atrioventricular block;
diseases of the thyroid gland;
heart rhythm disturbances.

It should be understood that the fact that papaverine can be used while carrying a child does not give a reason to self-medicate. This drug should be prescribed by a competent specialist if indicated and in the absence of contraindications.

allergic manifestations (skin rashes and itching);
heart rhythm disturbances;
lowering pressure below acceptable indicators;
drowsiness;
dizziness;
difficulty urinating and defecating;
attacks of nausea and vomiting.

With the manifestation of any adverse reactions you should consult a doctor for symptomatic treatment. In some clinical situations, it may be necessary to admit the patient to a hospital for medical supervision of her condition.

Method of using suppositories with papaverine during pregnancy

Features of the method of using papaverine depend on the trimester and the clinical situation. The answer to the question of where papaverine suppositories are inserted during pregnancy is unambiguous: these suppositories are used rectally, that is, they are inserted into the rectum. Under the influence of body temperature, the suppositories dissolve, and the active substance enters the bloodstream.

How to insert papaverine candles

Suppositories with an antispasmodic substance should be inserted in the supine position, in this sequence:

first, you must thoroughly wash your hands and wipe them dry with a clean towel;
then you should separate one candle from the contour packaging and carefully remove it from the cell;
lie on your side, slightly raise the leg, which is on top, and insert the suppository into the rectum;
then it is necessary to lie down for a while so that the active substance is released and enters the blood vessels.

Most often, the drug is prescribed 2-3 times a day at regular intervals. The duration of their use is from several days to three weeks. The duration of the course of treatment depends on the specific clinical situation.

Opinion of doctors on the use of papaverine

According to experts, papaverine in the form of a drug for rectal administration is safe for the health of the expectant mother and child. However, self-medication and dose adjustments should not be allowed without specialist advice. Exceeding the prescribed dosage can lead to a deterioration in the well-being of a woman, up to the need for hospitalization.

Dose adjustment when the clinical situation changes is carried out only by the attending physician.

Papaverine does not have any negative impacts directly to the fetus. This drug is approved for use at any time of bearing a child, provided there are indications and no contraindications. During the carrying of a child, the appointment of any kind of medication always causes future mother many questions and concerns.

A detailed study of the instructions for the drug, consultation with a doctor, familiarization with the thematic literature will help get rid of anxiety.

Suppositories with papaverine hydrochloride are safe for the child's body and cannot harm him. It should be accepted that adherence to the dosages recommended by the specialist will minimize the likelihood of adverse reactions on the part of the mother's body.

Therefore, the most important thing is to regularly consult with doctors and take any therapeutic measures only when prescribed by a gynecologist or other medical specialist.

Doctors prescribe Papaverine during pregnancy in ampoules or suppositories to achieve relaxation of the walls, contraction of the uterus. It also helps relieve muscle tone. When carrying a fetus, spasms of muscles, smooth muscles of the uterus and internal genital organs of a woman are suppressed under the influence of the hormone progesterone, preventing miscarriage. If it is not enough, there is a threat of termination of pregnancy, miscarriage or premature birth. From this, Papaverine helps.

What is papaverine taken for?

To improve the situation with the tone of the uterus and relieve spasms, papaverine suppositories are prescribed during pregnancy. This antispasmodic agent reduces pressure, improves blood circulation, relaxes the muscles of the uterus, and has a positive effect on the fetus, preventing the threat of miscarriage. If you take a large dose, you can feel the sedative effect of the central nervous system, the rhythm of the heart muscle decreases. Other indications for the appointment of Papaverine are:

cholecystitis, pylorospasm;
spastic colitis, renal colic;
haemorrhoids;
endarteritis.

Effects on the fetus

Papaverine for pregnant women relieves muscle spasms and may cause some side effects for the mother. In relation to the fetus, the agent is completely safe, because it does not penetrate through placental barrier... For several decades, women have been taking candles and ampoules when carrying a baby and, according to reviews, do not observe negative impact on children's organism.

Papaverine in early pregnancy

In the first trimester, taking papaverine suppositories is useful if the doctor finds initial stage gestation. This is accompanied by an increased tone of the uterus, and the active components of the drug eliminate this pathology and vascular spasms. In the second trimester, the indications for prescribing a medication are increased blood pressure and intrauterine pain. At this stage, Papaverine is prescribed as part of complex therapy with magnesium preparations.

At a later date

The third trimester of pregnancy is characterized in women by an overabundance of tension in the uterine walls, abdominal hardness, which is eliminated by suppositories and ampoules. Before childbirth, the drug may be prescribed to relax and prepare the cervix for dilation. During childbirth, the medication soothes the spasmodic pains from the contractions. Subject to the instructions and dosage of candles, there will be no harm from them.

Release form and composition

Medicinal product is available in the form of rectal suppositories, tablets and ampoules for intravenous administration. Papaverine injections and suppositories during pregnancy are prescribed more often, tablets for women expecting a future baby are contraindicated. The composition varies depending on the form:

Tablets weighing 0.01 or 0.04 g are produced in contour cell blisters of 10 pieces. They have a bitter taste, white color, and do not smell. The solution for injection has the format of 2% ampoules of 2 ml in carton 10 pieces each. Rectal suppositories for administration into the rectum contain 0.02 g of the active ingredient each, fixed in PVC blisters or foil packs of 10 pieces.

Instructions for use

The active ingredient of the drug is papaverine hydrochloride, which belongs to the opium alkaloids that act on smooth muscle elements. It causes relaxation, therefore, according to the pharmacological classification, it belongs to myotropic antispasmodics. The component inhibits some enzymes, lowers the level of calcium ions, reduces the tone of blood vessels and muscles.

In large doses, it eliminates the excitability of the heart, slows down intracardiac conduction, has a hypotensive, sedative effect. In combination with barbiturates, it enhances the antispasmodic effect. When taken simultaneously with tricyclic antidepressants, procainamide, reserpine, quinidine, the drug enhances the hypotensive effect.

Suppositories with papaverine during pregnancy

So that the remedy does not harm, the pregnant woman should follow the instructions for its use. Rectal suppositories must be inserted into anus after a bowel movement. It is better to do this while lying on your side. The course of treatment begins with concentration active substance in suppositories in the amount of 0.02 g, gradually increasing to 0.04 g. It is allowed to use no more than three suppositories per day.

Injection

The active ingredient of the pharmaceutical product is highly bioavailable, which allows subcutaneous, intramuscular or intravenous injections. Subcutaneous injections are performed in the upper arm or outer thigh, but not in the forearm, because the risk of hematoma increases. Intramuscular injections are injected into the upper lateral quadrant of the buttock. Before the injection, the contents of the ampoule are dissolved by 10-20 ml of saline, and it is injected very slowly. A single dosage is 0.1 g, the daily dosage does not exceed 0.3.

Contraindications

According to the instructions for use, rectal suppositories and ampoules for injection are not prescribed if there are contraindications:

problems with thyroid gland, liver, adrenal glands, kidneys;
increased intraocular pressure, glaucoma;
tachycardia;
rectal diseases;
disorder of the functioning of the bronchi;
hypersensitivity to components;
violation of intracardiac conduction, atrioventricular block;
self-administration of the drug;
with caution in case of recent traumatic brain injury, shock, hypothyroidism, supraventricular tachycardia.

Side effects and overdose

The properties of the side effects of the drug include allergic reactions, decreased pressure, constipation (constipation), atrio-ventricular blockade, bloating, nausea, impaired movement of food through the esophagus, increased activity of liver enzymes. With increased doses, manifestations of drowsiness, nausea, dizziness, sweating, eosinophilia are possible.

If the ampoules are administered too quickly, intravenous use is disrupted heartbeat... Overdose symptoms are double vision, weakness, increased fatigue... You can get rid of them with detoxification, symptomatic therapy. Gastric lavage, the use of sorbents effectively help, plus support for blood pressure is important special means.

Terms of sale and storage

The drug is dispensed by prescription, stored in a dry place protected from light, children at an air temperature of up to 25 degrees. The shelf life is two years.

Analogs

According to the active active ingredient, pharmacological action and the possibility of using during pregnancy, the following analogues of Papaverine of domestic or foreign production are distinguished:

Spasmol;
No-Shpa;
Drotaverin and Drotaverin Forte;
Dolche;
Nokhshaverin;
Pantestin;
Spazoverin;
Ple-Spa;
Drotaverine or Papaverine hydrochloride.

Papaverine price

You can buy the drug online or at a standard pharmacy. The cost depends on the form of release and the number of ampoules, tablets, suppositories. Approximate prices.

Suppositories with papaverine during pregnancy are prescribed to many women. For what purpose is this done, is it necessary to apply them and how correctly?

Papaverine hydrochloride - the active substance of this drug, has an antispasmodic property, that is, relieves spasm of blood vessels, muscles. But how can papaverine be used in suppositories during pregnancy and for how long, what is its benefit?

The fact is that all pregnant women in one way or another experience periodically hypertonicity of the uterus. At the same time, the sensations are rather unpleasant, as if everything is compressed inside, there may be painful sensations. Naturally, all this causes anxiety in the expectant mother. And she needs to worry less. That is why it is recommended to use suppositories with papaverine during pregnancy, and at any time, even at the very beginning of the gestation period. This drug is safe in small dosages.

And what happens if you do nothing with uterine spasm? If the spasm is quite strong, that is, it causes pain, and even more so if this situation repeated regularly - this can eventually lead to a miscarriage. A woman feels about the same spasms before childbirth, and in parallel with them, the cervix opens.

But unfortunately, papaverine during pregnancy is not salvation if a woman has severe pain, there was bloody discharge, but there is a chance to save the child, other candles are used for this - "Utrozhestan". This drug does not relieve spasm within a few minutes, as antispasmodics do, but often leads to the fact that within a few days the pain stops, and for a long time, the risk of miscarriage is reduced. This is because the composition of "Utrozhestan" includes the hormone progesterone, the lack of which leads to spontaneous interruption pregnancy.

Also, women often have a question - where to insert candles with papaverine during pregnancy? Into the rectum. Whereas "Utrozhestan" is used vaginally. Don't mix it up!

It is important to know that papaverine is not used as a treatment, unlike progesterone drugs. They can be used until mid-pregnancy or even later. Rectal suppositories with papaverine during pregnancy - symptomatic therapy, can be used at any time. Often these suppositories are prescribed together with an antispasmodic taken by mouth - "No-shpa" and analogues with the active substance "drotaverin".

The course of pregnancy can often be complicated by diseases of the expectant mother. Since the intake of medications at this time is significantly limited, many questions arise about the possibility of using one or another drug. In this article we will talk about papaverine rectal suppositories during pregnancy: can they be used and what they are prescribed for.

Papaverine belongs to the group of antispasmodic drugs: it relieves pain well, has a vasodilator effect and lowers blood pressure. It is produced in three forms: tablets, rectal suppositories and a solution for intramuscular or intravenous injection... They all have the same effect on the body. Choice specific form depends on the convenience of use and the individual indications of the patient.

Application area of this drug quite extensive, it is allowed to use it while waiting for a child. Most often, papaverine suppositories are prescribed during pregnancy, since they are easiest to use at home and they do not affect the gastrointestinal tract. Suppositories dissolve very quickly in the intestines and immediately begin their effect.

It should be noted right away that the appointment of this drug for a girl in a position is possible only by a qualified doctor. Despite the fact that many years of experience using papaverine hydrochloride suppositories during pregnancy speaks of their safety, only your gynecologist can prescribe them.

The instructions for the drug indicate that data on safe use during pregnancy, no. This only applies to clinical experiments.

However, papaverine has been used by expectant mothers for decades, and during this time observation has shown that it does not have an adverse effect on the fetus.

Thus, gynecologists and therapists often use Papaverine suppositories to treat certain diseases. The use of this drug during pregnancy should be due to the following reasons:

increased uterine tone, threatening favorable development fetus;
nervous overstrain of the expectant mother, requiring medication;
complex therapy of gestosis;
state of preeclampsia and eclampsia;
high blood pressure in a girl;
spasms and spastic pains of organs gastrointestinal tract with colitis, cholecystitis and other diseases;
cerebral vasospasm;
organ diseases genitourinary system(kidney stones, cystitis, etc.).

When using rectal suppositories, the effect occurs immediately after they are dissolved in the colon. Papaverine has the following effects on the body of the expectant mother:

relaxes smooth muscles and relieves muscle spasms various bodies,
lowers blood pressure,
long-term use or high dosages reduce the excitability of the heart muscle,
has a sedative effect on the central nervous system.

Papaverine in suppositories during pregnancy should be used in the dosage prescribed by the attending physician. Usually, girls are assigned one papaverine suppository from two to four times per day, depending on the severity of the disease and the condition of the expectant mother. Never exceed the indicated dosage and monitor the body's response to the drug administration. Side effects include:

nausea, bloating, and constipation
tachycardia,
lowering blood pressure,
drowsiness,
allergic reactions.

Also, pay Special attention for contraindications to the use of papaverine.

Many pregnant women try to refrain from taking any medication for fear of harming their baby. However, hypertonicity of the uterus is not one of those conditions that can be ignored. Excessive activity muscle mass during pregnancy often leads to miscarriage or premature birth. To avoid such troubles, doctors prescribe papaverine suppositories to women. It is believed that this drug is not harmful to the baby and mother, despite the fact that clinical studies regarding its safety during gestation have not been conducted.

Is papaverine hydrochloride harmful during pregnancy

The instruction for the drug states that clinical studies on its effect on the body of expectant mothers have not been carried out, therefore it is contraindicated during the period of bearing a child. However, the situation is not so straightforward.

Medicines based on papaverine have been successfully used for six decades. During this time, the medication was used by several generations of pregnant women, who gave birth to more than one million absolutely healthy babies.

Thus, long-term observations of obstetricians-gynecologists and pediatricians show that rectal suppositories with papaverine, if indicated and appropriate use, provide positive impact on the condition of expectant mothers and do not affect intrauterine development fetus.

Composition and action of rectal suppositories

The action of papaverine is based on smooth muscle relaxation internal organs: stomach, intestines, bronchi, lungs, blood vessels and uterus. The relaxing effect does not extend to the striated muscles, which means that the muscles of the skeleton and heart will work as before.

For the first time, papaverine was isolated in the middle of the 19th century from the opium poppy. This alkaloid gained considerable popularity in the fifties of the last century, when its industrial production was established.

Thus, papaverine suppositories have a complex effect on the female body:

relieve excessive tone and suppress contractions of the uterus and other muscle organs;
have a vasodilating effect;
lower blood pressure.

Suppositories with papaverine are the most effective form of medicine for pregnant women

In addition to suppositories, many manufacturers produce papaverine hydrochloride preparations in the form of tablets and solutions for intravenous administration. However, for pregnant women, doctors most often prescribe rectal suppositories, considering them a safer and more effective dosage form.

Indications

Because of hormonal changes v female body during pregnancy, the amount of progesterone, a hormone involved in muscle relaxation, decreases. As a result of this, the uterus can actively contract and even be constantly in increased tone. A similar condition - serious threat for the development and life of the fetus. Usually, papaverine suppositories are prescribed for pregnant women with high tone uterus threatening spontaneous miscarriage or premature birth.

In addition, doctors prescribe this antispasmodic for complex treatment conditions such as:

inflammation of the gallbladder;
renal colic;
diseases of the gastrointestinal tract (colitis, flatulence, functional disorders intestines);
inflammation urinary tract(urethritis and cystitis);
gestosis (complication of pregnancy, accompanied by swelling, seizures, high blood pressure).

Suppositories with papaverine also have a sedative effect, normalize the heart rate. However, a similar effect is observed only after prolonged use of the drug.

Contraindications

Medicines with papaverine are prohibited in any dosage forms with diseases and conditions such as:

intolerance to the components of the drug;
atrioventricular block (heart rhythm disturbances);
liver failure;
increased intraocular pressure.

With extreme caution, papaverine suppositories should be used for women diagnosed with hypothyroidism, tachycardia, adrenal and kidney disorders. It is imperative to inform your doctor about the presence of these problems.

Constipation and other possible side effects

The undesirable consequences of taking suppositories with papaverine are quite rare and, as a rule, depend on individual characteristics pregnant woman. Among side effects are noted:

allergic reactions;
nausea;
drowsiness;
bowel disruption (constipation);
increased sweating;
arterial hypotension (lowering pressure).

Low blood pressure is one of the possible side effects when taking suppositories with papaverine

Taking the drug by trimester

Usually, candles with papaverine are not used alone. Depending on the trimester and the severity of the disease, this antispasmodic is often prescribed in combination with other medicines.

First trimester

Early pregnancy list safe medicines very limited due to the unformed placenta. Meanwhile, papaverine is in great demand as an antispasmodic.

In the first weeks of pregnancy, some women suffer from uterine hypertonicity associated with inadequate progesterone production. That is why papaverine is prescribed together with hormonal medications.

Second trimester

During this period, the list of approved drugs is significantly expanded. In the case of hypertonia, the threat of miscarriage, doctors prescribe more serious medications that inhibit the contractile activity of the uterus - for example, Ginipral, Bricanil or injections of magnesia.

Papaverine suppositories in the second trimester are most often used to relieve pain in renal colic, in diseases of the gastrointestinal tract and urinary system, accompanied by spasms, as well as to reduce pressure.

Third trimester

In late pregnancy, rectal suppositories with papaverine are prescribed in the following situations:

If the tension of the uterine muscles is too strong, and it is still far from the expected date of birth. In this case, steroid hormones are additionally prescribed.
Before childbirth, candles are used as indicators of "false" contractions. If, after the administration of the drug, the contractile activity of the uterus has stopped, it means that labor has not yet begun.
At 39 weeks of gestation, suppositories are used to prepare the cervix for labor.
In real contractions, the drug is prescribed to reduce pain.

Instructions for safe use

Suppositories with papaverine during the period of bearing a child are prescribed only by the attending doctor after full examination and clarification of the diagnosis. He also determines the dosage and duration of the course of therapy.

Pregnant women are usually prescribed one papaverine suppository several times a day at regular intervals. They are introduced into the rectum, lying on the side. This should be done with clean hands or with sterile gloves to avoid the entry of pathogenic microbes into the body.

The action of the active substance begins almost immediately after the dissolution of the rectal suppository. But for a lasting effect, you need to go through full course treatment prescribed by your doctor. Sometimes it is quite long (up to a month).

How can you replace candles with papaverine, including in the early stages?

Papaverine in the form of rectal suppositories does not have analogues containing the same active ingredient. If a woman is intolerant to papaverine, the doctor may prescribe antispasmodic medications that contain other active ingredients, but have a similar therapeutic effect.

Substitutes for papaverine suppositories are also preparations consisting of several active ingredients, one of which is papaverine.

Table: papaverine analogues prescribed during pregnancy

Name	Dosage forms	Active substance	Indications	Contraindications	Pregnancy use
	Pills; solution.	Drotaverine hydrochloride	Renal colic; bile colic; intestinal colic; spastic constipation; endarteritis; spasms of the uterus, threatening premature birth and miscarriage.	Intolerance to components; cardiogenic shock; arterial hypotension; glaucoma; severe renal and hepatic impairment.	According to the testimony of a doctor
	Solution; pills.	Drotaverine hydrochloride	Hypertonicity of the uterus; spasms of smooth muscles in diseases of the biliary tract; spasms of smooth muscles of the urinary system; spasms of the gastrointestinal tract; headache.	Severe renal failure; severe liver failure; severe heart failure; hypersensitivity to the drug; intolerance to galactose.	According to the testimony of a doctor
	Pills	Papaverine hydrochloride; dibazol.	Arterial hypertension; spasms of peripheral arteries and blood vessels of the brain; spasm of smooth muscles of internal organs; polio.	Disturbances in the conducting system of the heart; epilepsy; intolerance to the components.	Allowed with care
	Pills; solution; concentrate.	Hexoprenaline sulfate	Hypertonicity of the uterus; braking labor pains during childbirth; prevention of premature birth.	Thyrotoxicosis; tachyarrhythmia; myocarditis; arterial hypertension; cardiac ischemia; severe kidney and liver diseases; angle-closure glaucoma; intrauterine infection; hypersensitivity to components.	Allowed use from the II trimester

Photo gallery: antispasmodic drugs used during pregnancy

No-shpa - popular drug to relieve spasms, including in pregnant women
Drotaverin is a synthetic drug that reduces the tone of smooth muscles of internal organs and helps to reduce pain in spasms of various organs Ginipral is a drug that helps to reduce the tone and contractile activity of the uterus Papazol, like papaverine suppositories, contains papaverine hydrochloride